Traitement précoce du diabète de type 2 chez l'obèse après gastric bypass et diversion bilio-pancréatique: Rôle de l'axe entéro-insulinique

Translated title of the contribution: Early improvement in type 2 diabetes in obese patients following gastric bypass and bilio-pancreatic diversion: The role of the entero-insular axis

J. C. Lifante, W. B. Inabnet

Research output: Contribution to journalShort surveypeer-review

4 Scopus citations

Abstract

Improvement in Type 2 diabetes is seen in 80-98% of obese diabetic patients who undergo gastric bypass or bilio-pancreatic diversion. This improvement is evident early after the operation before significant weight loss has occurred. Although numerous teams have extensively studied the physiology of this early post-bypass amelioration of type 2 diabetes, the exact mechanism of diabetes remission remains unclear. Studies have focused on changes in the entero-insular axis, which is mediated in part by the interaction of insulinotropic hormones GIP and GIP 1 on the beta islet cells of the pancreas. Other mechanisms which have been postulated focus on the adipo-insular axis; the actions of adiponectin and leptin seem to have an important role in insulin resistance but their action is weight-loss dependent. Post-operative caloric restriction may also contribute to the early resolution of type 2 diabetes observed after gastric bypass and bilio- pancreatic diversion.

Translated title of the contributionEarly improvement in type 2 diabetes in obese patients following gastric bypass and bilio-pancreatic diversion: The role of the entero-insular axis
Original languageFrench
Pages (from-to)549-555
Number of pages7
JournalJournal de Chirurgie
Volume145
Issue number6
DOIs
StatePublished - 2008

Keywords

  • Bilio pancreatic diversion
  • Entero insular axis
  • GLP-1
  • Gut peptides
  • Incretin
  • Obesity
  • Type 2 diabetes

ASJC Scopus subject areas

  • Surgery

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