Objective. Transcranial Doppler (TCD) is used during cardiopulmonary bypass (CPB) to assess cerebral emboli and to estimate cerebral perfusion. We sought to compare TCD middle cerebral artery blood flow velocity (Vmca) to 133Xe clearance cerebral blood flow (CBF) measurements during mild hypothermic CPB thus determining its utility in cerebral perfusion assessment. Methods. Thirty-four patients undergoing mild hypothermic CPB (35 °C) were studied and had comparisons of Vmca and 133Xe CBF at three time intervals, 10, 30 and 60 min after the institution of CPB. Linear regression analysis was performed on data from each of the 3 intervals as well as for pooled data from all 3 periods. Results. The correlation coefficients for the 3 time periods were, r = 0.32 (p = 0.12), r = 0.32 (p = 0.11), r = 0.48 (p = 0.02), respectively. The pooled data correlation had a coefficient of 0.34 (p = 0.003). Conclusion. These findings suggest that TCD Vmca is a relatively poor correlate of CBF during mild hypothermic CPB.
|Number of pages||5|
|Journal||Journal of Clinical Monitoring and Computing|
|State||Published - Jan 1998|
Bibliographical noteFunding Information:
Supported by grants: R01-AG09663, and GM08600-02 National Institutes of Health; Anesthesia Patient Safety Foundation; and 95010970, American Heart Association.
- Cardiopulmonary bypass
- Transcranial doppler
- Xe clearance cerebral blood flow
ASJC Scopus subject areas
- Health Informatics
- Critical Care and Intensive Care Medicine
- Anesthesiology and Pain Medicine