Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead

Hamed Ekhtiari; Hosna Tavakoli; Giovanni Addolorato; Chris Baeken; Antonello Bonci; Salvatore Campanella; Luis Castelo-Branco; Gaëlle Challet-Bouju; Vincent P. Clark; Eric Claus; Pinhas N. Dannon; Alessandra Del Felice; Tess den Uyl; Marco Diana; Massimo di Giannantonio; John R. Fedota; Paul Fitzgerald; Luigi Gallimberti; Marie Grall-Bronnec; Sarah C. Herremans; Martin J. Herrmann; Asif Jamil; Eman Khedr; Christos Kouimtsidis; Karolina Kozak; Evgeny Krupitsky; Claus Lamm; William V. Lechner; Graziella Madeo; Nastaran Malmir; Giovanni Martinotti; William M. McDonald; Chiara Montemitro; Ester M. Nakamura-Palacios; Mohammad Nasehi; Xavier Noël; Masoud Nosratabadi; Martin Paulus; Mauro Pettorruso; Basant Pradhan; Samir K. Praharaj; Haley Rafferty; Gregory Sahlem; Betty jo Salmeron; Anne Sauvaget; Renée S. Schluter; Carmen Sergiou; Alireza Shahbabaie; Christine Sheffer; Primavera A. Spagnolo; Vaughn R. Steele; Ti fei Yuan; Josanne D.M. van Dongen; Vincent Van Waes; Ganesan Venkatasubramanian; Antonio Verdejo-García; Ilse Verveer; Justine W. Welsh; Michael J. Wesley; Katie Witkiewitz; Fateme Yavari; Mohammad Reza Zarrindast; Laurie Zawertailo; Xiaochu Zhang; Yoon Hee Cha; Tony P. George; Flavio Frohlich; Anna E. Goudriaan; Shirley Fecteau; Stacey B. Daughters; Elliot A. Stein; Felipe Fregni; Michael A. Nitsche; Abraham Zangen; Marom Bikson; Colleen A. Hanlon

doi:10.1016/j.neubiorev.2019.06.007

Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead

Hamed Ekhtiari, Hosna Tavakoli, Giovanni Addolorato, Chris Baeken, Antonello Bonci, Salvatore Campanella, Luis Castelo-Branco, Gaëlle Challet-Bouju, Vincent P. Clark, Eric Claus, Pinhas N. Dannon, Alessandra Del Felice, Tess den Uyl, Marco Diana, Massimo di Giannantonio, John R. Fedota, Paul Fitzgerald, Luigi Gallimberti, Marie Grall-Bronnec, Sarah C. HerremansMartin J. Herrmann, Asif Jamil, Eman Khedr, Christos Kouimtsidis, Karolina Kozak, Evgeny Krupitsky, Claus Lamm, William V. Lechner, Graziella Madeo, Nastaran Malmir, Giovanni Martinotti, William M. McDonald, Chiara Montemitro, Ester M. Nakamura-Palacios, Mohammad Nasehi, Xavier Noël, Masoud Nosratabadi, Martin Paulus, Mauro Pettorruso, Basant Pradhan, Samir K. Praharaj, Haley Rafferty, Gregory Sahlem, Betty jo Salmeron, Anne Sauvaget, Renée S. Schluter, Carmen Sergiou, Alireza Shahbabaie, Christine Sheffer, Primavera A. Spagnolo, Vaughn R. Steele, Ti fei Yuan, Josanne D.M. van Dongen, Vincent Van Waes, Ganesan Venkatasubramanian, Antonio Verdejo-García, Ilse Verveer, Justine W. Welsh, Michael J. Wesley, Katie Witkiewitz, Fateme Yavari, Mohammad Reza Zarrindast, Laurie Zawertailo, Xiaochu Zhang, Yoon Hee Cha, Tony P. George, Flavio Frohlich, Anna E. Goudriaan, Shirley Fecteau, Stacey B. Daughters, Elliot A. Stein, Felipe Fregni, Michael A. Nitsche, Abraham Zangen, Marom Bikson, Colleen A. Hanlon

Research output: Contribution to journal › Review article › peer-review

236 Scopus citations

Abstract

There is growing interest in non-invasive brain stimulation (NIBS) as a novel treatment option for substance-use disorders (SUDs). Recent momentum stems from a foundation of preclinical neuroscience demonstrating links between neural circuits and drug consuming behavior, as well as recent FDA-approval of NIBS treatments for mental health disorders that share overlapping pathology with SUDs. As with any emerging field, enthusiasm must be tempered by reason; lessons learned from the past should be prudently applied to future therapies. Here, an international ensemble of experts provides an overview of the state of transcranial-electrical (tES) and transcranial-magnetic (TMS) stimulation applied in SUDs. This consensus paper provides a systematic literature review on published data – emphasizing the heterogeneity of methods and outcome measures while suggesting strategies to help bridge knowledge gaps. The goal of this effort is to provide the community with guidelines for best practices in tES/TMS SUD research. We hope this will accelerate the speed at which the community translates basic neuroscience into advanced neuromodulation tools for clinical practice in addiction medicine.

Original language	English
Pages (from-to)	118-140
Number of pages	23
Journal	Neuroscience and Biobehavioral Reviews
Volume	104
DOIs	https://doi.org/10.1016/j.neubiorev.2019.06.007
State	Published - Sep 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd

Funding

Xavier Noël is supported by a grant of the Belgian Fund for Scientific Research (grant PDR/OL T.0146.18 ). Anna E. Goudriaan and Renée S. Schluter are funded by an innovative VIDI grant awarded to AG (grant number 91713354 ) by the Netherlands Health Research Organization (ZonMW). Elliot Stein and Vaughn Steele are supported by the Intramural Research Program of the National Institute on Drug Abuse (NIDA), National Institutes of Health, Baltimore, Maryland and The Center on Compulsive Behavior . Antonio Verdejo-García is supported by Australian Medical Research Future Fund ( MRF1141214 ). Laurie Zawertailo received funding from Canadian Institutes of Health Research, Canadian Cancer Society, Ontario Ministry of Health , and Global Research Awards in Nicotine Dependence . Flavio Frohlich received funding from NIH , Bran and Behavior Research Foundation , Human Frontiers Science Program , Tal Medical , and the Neurocare Group . Shirley Fecteau is supported by the Canada Research Chair in Cognitive Neuroplasticity . Stacey Daughters is supported by the NIH/NIDA ( R01DA026424 ). Michael A. Nitsche receives funding from the German Research Foundation (DFG; SFB 1280 Project A6), and the German Federal Ministry of Education and Research (BMBF, GCBS grant 01EE1403C ). Coleen A. Hanlon received funding from the NIDA ( R01DA04447 ) and NIAAA ( P50AA010761 ). Vincent Van Waes is supported by the Fondation pour la Recherche en Alcoologie (FRA) and the Région Bourgogne Franche-Comté . Ganesan Venkatasubramanian is supported by the Swarnajayanti Fellowship Grant ( DST/SJF/LSA-02/2014-15 ) by the Department of Science and Technology, Government of India . Michael J. Wesley receives funding from the NIDA ( K01DA043652 ; R01DA045023 and R01DA047368 ). Xavier Noël is supported by a grant of the Belgian Fund for Scientific Research (grant PDR/OL T.0146.18). Anna E. Goudriaan and Renée S. Schluter are funded by an innovative VIDI grant awarded to AG (grant number 91713354) by the Netherlands Health Research Organization (ZonMW). Elliot Stein and Vaughn Steele are supported by the Intramural Research Program of the National Institute on Drug Abuse (NIDA), National Institutes of Health, Baltimore, Maryland and The Center on Compulsive Behavior. Antonio Verdejo-García is supported by Australian Medical Research Future Fund (MRF1141214). Laurie Zawertailo received funding from Canadian Institutes of Health Research, Canadian Cancer Society, Ontario Ministry of Health, and Global Research Awards in Nicotine Dependence. Flavio Frohlich received funding from NIH, Bran and Behavior Research Foundation, Human Frontiers Science Program, Tal Medical, and the Neurocare Group. Shirley Fecteau is supported by the Canada Research Chair in Cognitive Neuroplasticity. Stacey Daughters is supported by the NIH/NIDA (R01DA026424). Michael A. Nitsche receives funding from the German Research Foundation (DFG; SFB 1280 Project A6), and the German Federal Ministry of Education and Research (BMBF, GCBS grant 01EE1403C). Coleen A. Hanlon received funding from the NIDA (R01DA04447) and NIAAA (P50AA010761). Vincent Van Waes is supported by the Fondation pour la Recherche en Alcoologie (FRA) and the Région Bourgogne Franche-Comté. Ganesan Venkatasubramanian is supported by the Swarnajayanti Fellowship Grant (DST/SJF/LSA-02/2014-15) by the Department of Science and Technology, Government of India. Michael J. Wesley receives funding from the NIDA (K01DA043652; R01DA045023 and R01DA047368).

Funders	Funder number
Australian Medical Research Future Fund	MRF1141214
Belgian National Fund for Scientific Research	PDR/OL T.0146.18, 91713354
Fondation pour la Recherche en Alcoologie
GCBS
Netherlands Organization for Health Research and Development
Neurocare Group
Ontario Ministry of Health and Long-Term Care Academic Health Sciences Centres Alternate Funding Plan Innovation Fund, Canada
Tal Medical
National Institutes of Health (NIH)
National Institute on Drug Abuse	R01DA047368, R01DA045023, R01DA04447, K01DA043652, ZIADA000470
National Institute on Alcohol Abuse and Alcoholism	P50AA010761
Brain and Behavior Research Foundation
California Department of Fish and Game
Canadian Institutes of Health Research
Canadian Cancer Society Research Institute
International Human Frontier Science Program Organization
Department of Science and Technology, Ministry of Science and Technology, India
Deutsche Forschungsgemeinschaft	SFB 1280
Canada Excellence Research Chairs, Government of Canada	R01DA026424
ZonMw Memorabel
Bundesministerium für Bildung und Forschung	01EE1403C
Conseil régional de Bourgogne-Franche-Comté	DST/SJF/LSA-02/2014-15
Norges Idrettshøgskole

Keywords

Addiction
NIBS
Non-invasive brain stimulation
Psychiatry
Substance use disorder
Transcranial electrical stimulation
Transcranial magnetic stimulation
rTMS
tDCS
tES

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Behavioral Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.neubiorev.2019.06.007

Cite this

Ekhtiari, H., Tavakoli, H., Addolorato, G., Baeken, C., Bonci, A., Campanella, S., Castelo-Branco, L., Challet-Bouju, G., Clark, V. P., Claus, E., Dannon, P. N., Del Felice, A., den Uyl, T., Diana, M., di Giannantonio, M., Fedota, J. R., Fitzgerald, P., Gallimberti, L., Grall-Bronnec, M., ... Hanlon, C. A. (2019). Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead. Neuroscience and Biobehavioral Reviews, 104, 118-140. https://doi.org/10.1016/j.neubiorev.2019.06.007

@article{89f0ba15e1594f64ab07d47723683929,

title = "Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead",

abstract = "There is growing interest in non-invasive brain stimulation (NIBS) as a novel treatment option for substance-use disorders (SUDs). Recent momentum stems from a foundation of preclinical neuroscience demonstrating links between neural circuits and drug consuming behavior, as well as recent FDA-approval of NIBS treatments for mental health disorders that share overlapping pathology with SUDs. As with any emerging field, enthusiasm must be tempered by reason; lessons learned from the past should be prudently applied to future therapies. Here, an international ensemble of experts provides an overview of the state of transcranial-electrical (tES) and transcranial-magnetic (TMS) stimulation applied in SUDs. This consensus paper provides a systematic literature review on published data – emphasizing the heterogeneity of methods and outcome measures while suggesting strategies to help bridge knowledge gaps. The goal of this effort is to provide the community with guidelines for best practices in tES/TMS SUD research. We hope this will accelerate the speed at which the community translates basic neuroscience into advanced neuromodulation tools for clinical practice in addiction medicine.",

keywords = "Addiction, NIBS, Non-invasive brain stimulation, Psychiatry, Substance use disorder, Transcranial electrical stimulation, Transcranial magnetic stimulation, rTMS, tDCS, tES",

author = "Hamed Ekhtiari and Hosna Tavakoli and Giovanni Addolorato and Chris Baeken and Antonello Bonci and Salvatore Campanella and Luis Castelo-Branco and Ga{\"e}lle Challet-Bouju and Clark, \{Vincent P.\} and Eric Claus and Dannon, \{Pinhas N.\} and \{Del Felice\}, Alessandra and \{den Uyl\}, Tess and Marco Diana and \{di Giannantonio\}, Massimo and Fedota, \{John R.\} and Paul Fitzgerald and Luigi Gallimberti and Marie Grall-Bronnec and Herremans, \{Sarah C.\} and Herrmann, \{Martin J.\} and Asif Jamil and Eman Khedr and Christos Kouimtsidis and Karolina Kozak and Evgeny Krupitsky and Claus Lamm and Lechner, \{William V.\} and Graziella Madeo and Nastaran Malmir and Giovanni Martinotti and McDonald, \{William M.\} and Chiara Montemitro and Nakamura-Palacios, \{Ester M.\} and Mohammad Nasehi and Xavier No{\"e}l and Masoud Nosratabadi and Martin Paulus and Mauro Pettorruso and Basant Pradhan and Praharaj, \{Samir K.\} and Haley Rafferty and Gregory Sahlem and Salmeron, \{Betty jo\} and Anne Sauvaget and Schluter, \{Ren{\'e}e S.\} and Carmen Sergiou and Alireza Shahbabaie and Christine Sheffer and Spagnolo, \{Primavera A.\} and Steele, \{Vaughn R.\} and Yuan, \{Ti fei\} and \{van Dongen\}, \{Josanne D.M.\} and \{Van Waes\}, Vincent and Ganesan Venkatasubramanian and Antonio Verdejo-Garc{\'i}a and Ilse Verveer and Welsh, \{Justine W.\} and Wesley, \{Michael J.\} and Katie Witkiewitz and Fateme Yavari and Zarrindast, \{Mohammad Reza\} and Laurie Zawertailo and Xiaochu Zhang and Cha, \{Yoon Hee\} and George, \{Tony P.\} and Flavio Frohlich and Goudriaan, \{Anna E.\} and Shirley Fecteau and Daughters, \{Stacey B.\} and Stein, \{Elliot A.\} and Felipe Fregni and Nitsche, \{Michael A.\} and Abraham Zangen and Marom Bikson and Hanlon, \{Colleen A.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = sep,

doi = "10.1016/j.neubiorev.2019.06.007",

language = "English",

volume = "104",

pages = "118--140",

}

Ekhtiari, H, Tavakoli, H, Addolorato, G, Baeken, C, Bonci, A, Campanella, S, Castelo-Branco, L, Challet-Bouju, G, Clark, VP, Claus, E, Dannon, PN, Del Felice, A, den Uyl, T, Diana, M, di Giannantonio, M, Fedota, JR, Fitzgerald, P, Gallimberti, L, Grall-Bronnec, M, Herremans, SC, Herrmann, MJ, Jamil, A, Khedr, E, Kouimtsidis, C, Kozak, K, Krupitsky, E, Lamm, C, Lechner, WV, Madeo, G, Malmir, N, Martinotti, G, McDonald, WM, Montemitro, C, Nakamura-Palacios, EM, Nasehi, M, Noël, X, Nosratabadi, M, Paulus, M, Pettorruso, M, Pradhan, B, Praharaj, SK, Rafferty, H, Sahlem, G, Salmeron, BJ, Sauvaget, A, Schluter, RS, Sergiou, C, Shahbabaie, A, Sheffer, C, Spagnolo, PA, Steele, VR, Yuan, TF, van Dongen, JDM, Van Waes, V, Venkatasubramanian, G, Verdejo-García, A, Verveer, I, Welsh, JW, Wesley, MJ, Witkiewitz, K, Yavari, F, Zarrindast, MR, Zawertailo, L, Zhang, X, Cha, YH, George, TP, Frohlich, F, Goudriaan, AE, Fecteau, S, Daughters, SB, Stein, EA, Fregni, F, Nitsche, MA, Zangen, A, Bikson, M & Hanlon, CA 2019, 'Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead', Neuroscience and Biobehavioral Reviews, vol. 104, pp. 118-140. https://doi.org/10.1016/j.neubiorev.2019.06.007

Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead. / Ekhtiari, Hamed; Tavakoli, Hosna; Addolorato, Giovanni et al.
In: Neuroscience and Biobehavioral Reviews, Vol. 104, 09.2019, p. 118-140.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine

T2 - A consensus paper on the present state of the science and the road ahead

AU - Ekhtiari, Hamed

AU - Tavakoli, Hosna

AU - Addolorato, Giovanni

AU - Baeken, Chris

AU - Bonci, Antonello

AU - Campanella, Salvatore

AU - Castelo-Branco, Luis

AU - Challet-Bouju, Gaëlle

AU - Clark, Vincent P.

AU - Claus, Eric

AU - Dannon, Pinhas N.

AU - Del Felice, Alessandra

AU - den Uyl, Tess

AU - Diana, Marco

AU - di Giannantonio, Massimo

AU - Fedota, John R.

AU - Fitzgerald, Paul

AU - Gallimberti, Luigi

AU - Grall-Bronnec, Marie

AU - Herremans, Sarah C.

AU - Herrmann, Martin J.

AU - Jamil, Asif

AU - Khedr, Eman

AU - Kouimtsidis, Christos

AU - Kozak, Karolina

AU - Krupitsky, Evgeny

AU - Lamm, Claus

AU - Lechner, William V.

AU - Madeo, Graziella

AU - Malmir, Nastaran

AU - Martinotti, Giovanni

AU - McDonald, William M.

AU - Montemitro, Chiara

AU - Nakamura-Palacios, Ester M.

AU - Nasehi, Mohammad

AU - Noël, Xavier

AU - Nosratabadi, Masoud

AU - Paulus, Martin

AU - Pettorruso, Mauro

AU - Pradhan, Basant

AU - Praharaj, Samir K.

AU - Rafferty, Haley

AU - Sahlem, Gregory

AU - Salmeron, Betty jo

AU - Sauvaget, Anne

AU - Schluter, Renée S.

AU - Sergiou, Carmen

AU - Shahbabaie, Alireza

AU - Sheffer, Christine

AU - Spagnolo, Primavera A.

AU - Steele, Vaughn R.

AU - Yuan, Ti fei

AU - van Dongen, Josanne D.M.

AU - Van Waes, Vincent

AU - Venkatasubramanian, Ganesan

AU - Verdejo-García, Antonio

AU - Verveer, Ilse

AU - Welsh, Justine W.

AU - Wesley, Michael J.

AU - Witkiewitz, Katie

AU - Yavari, Fateme

AU - Zarrindast, Mohammad Reza

AU - Zawertailo, Laurie

AU - Zhang, Xiaochu

AU - Cha, Yoon Hee

AU - George, Tony P.

AU - Frohlich, Flavio

AU - Goudriaan, Anna E.

AU - Fecteau, Shirley

AU - Daughters, Stacey B.

AU - Stein, Elliot A.

AU - Fregni, Felipe

AU - Nitsche, Michael A.

AU - Zangen, Abraham

AU - Bikson, Marom

AU - Hanlon, Colleen A.

PY - 2019/9

Y1 - 2019/9

N2 - There is growing interest in non-invasive brain stimulation (NIBS) as a novel treatment option for substance-use disorders (SUDs). Recent momentum stems from a foundation of preclinical neuroscience demonstrating links between neural circuits and drug consuming behavior, as well as recent FDA-approval of NIBS treatments for mental health disorders that share overlapping pathology with SUDs. As with any emerging field, enthusiasm must be tempered by reason; lessons learned from the past should be prudently applied to future therapies. Here, an international ensemble of experts provides an overview of the state of transcranial-electrical (tES) and transcranial-magnetic (TMS) stimulation applied in SUDs. This consensus paper provides a systematic literature review on published data – emphasizing the heterogeneity of methods and outcome measures while suggesting strategies to help bridge knowledge gaps. The goal of this effort is to provide the community with guidelines for best practices in tES/TMS SUD research. We hope this will accelerate the speed at which the community translates basic neuroscience into advanced neuromodulation tools for clinical practice in addiction medicine.

AB - There is growing interest in non-invasive brain stimulation (NIBS) as a novel treatment option for substance-use disorders (SUDs). Recent momentum stems from a foundation of preclinical neuroscience demonstrating links between neural circuits and drug consuming behavior, as well as recent FDA-approval of NIBS treatments for mental health disorders that share overlapping pathology with SUDs. As with any emerging field, enthusiasm must be tempered by reason; lessons learned from the past should be prudently applied to future therapies. Here, an international ensemble of experts provides an overview of the state of transcranial-electrical (tES) and transcranial-magnetic (TMS) stimulation applied in SUDs. This consensus paper provides a systematic literature review on published data – emphasizing the heterogeneity of methods and outcome measures while suggesting strategies to help bridge knowledge gaps. The goal of this effort is to provide the community with guidelines for best practices in tES/TMS SUD research. We hope this will accelerate the speed at which the community translates basic neuroscience into advanced neuromodulation tools for clinical practice in addiction medicine.

KW - Addiction

KW - NIBS

KW - Non-invasive brain stimulation

KW - Psychiatry

KW - Substance use disorder

KW - Transcranial electrical stimulation

KW - Transcranial magnetic stimulation

KW - rTMS

KW - tDCS

KW - tES

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UR - http://www.scopus.com/inward/citedby.url?scp=85068939477&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2019.06.007

DO - 10.1016/j.neubiorev.2019.06.007

M3 - Review article

C2 - 31271802

AN - SCOPUS:85068939477

SN - 0149-7634

VL - 104

SP - 118

EP - 140

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

ER -

Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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