Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients

Turgut Durduran, Chao Zhou, Brian L. Edlow, Guoqiang Yu, Regine Choe, Meeri N. Kim, Brett L. Cucchiara, Mary E. Putt, Qaisar Shah, Scott E. Kasner, Joel H. Greenberg, Arjun G. Yodh, John A. Detrey

Research output: Contribution to journalArticlepeer-review

135 Scopus citations


"Diffuse correlation spectroscopy" (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with "near-infrared spectroscopy" (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30°, 15°, 0°, -5° and 0° angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (Hb02) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.

Original languageEnglish
Pages (from-to)3884-3902
Number of pages19
JournalOptics Express
Issue number5
StatePublished - Mar 2 2009

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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