Transcription and nucleotide excision repair - reflections, considerations and recent biochemical insights

Errol C. Friedberg, A. Jane Bardwell, Lee Bardwell, Zhigang Wang, Grigory Dianov

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Recent years have witnessed considerable progress in the definition of the preferential repair of actively transcribed genes. Equally impressive progress has been achieved in our understanding of the genetic and biochemical complexity of the DNA-repair process called nucleotide excision repair (NER). Most recently studies in several laboratories have yielded observations which provide insights about how the processes of transcription and NER may be linked in prokaryotic and eukaryotic cells.

Original languageEnglish
Pages (from-to)5-14
Number of pages10
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Issue number1
StatePublished - May 1 1994

Bibliographical note

Funding Information:
This paper is dedicated to the memory of Professor Fritz Sobels, in recognition of his numerous contributions to promoting the fields of DNA damage, repair and mutagenesis. We wish to acknowledge extensive scientific collaboration with Dr. Roger D. Kornberg and his colleagues William J. Feaver and Jesper Q. Svejstrup, in the Department of Cell Biology, Stanford University. We also thank our laboratory colleagues for review of the manuscript and for many helpful discussions. The studies in the senior author's laboratory were supported by research grant CA12428 from the USPHS.


  • NER
  • Nucleotide excision repair
  • Transcribed genes
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis


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