Transcription-coupled repair deficiency and mutations in human mismatch repair genes

Isabel Mellon, Deepak K. Rajpal, Minoru Koi, C. Richard Boland, Gregory N. Champe

Research output: Contribution to journalArticlepeer-review

246 Scopus citations

Abstract

Deficiencies in mismatch repair have been linked to a common cancer predisposition syndrome in humans, hereditary nonpolyposis colorectal cancer (HNPCC), and a subset of sporadic cancers. Here, several mismatch repair-deficient tumor cell lines and HNPCC-derived lymphoblastoid cell lines were found to be deficient in an additional DNA repair process termed transcription-coupled repair (TCR). The TCR defect was corrected in a mutant cell line whose mismatch repair deficiency had been corrected by chromosome transfer. Thus, the connection between excision repair and mismatch repair previously described in Escherichia coli extends to humans. These results imply that deficiencies in TCR and exposure to carcinogens present in the environment may contribute to the etiology of tumors associated with genetic defects in mismatch repair.

Original languageEnglish
Pages (from-to)557-560
Number of pages4
JournalScience
Volume272
Issue number5261
DOIs
StatePublished - Apr 26 1996

ASJC Scopus subject areas

  • General

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