TY - JOUR
T1 - Transcription factor DUO1 generated by neo-functionalization is associated with evolution of sperm differentiation in plants
AU - Higo, Asuka
AU - Kawashima, Tomokazu
AU - Borg, Michael
AU - Zhao, Mingmin
AU - López-Vidriero, Irene
AU - Sakayama, Hidetoshi
AU - Montgomery, Sean A.
AU - Sekimoto, Hiroyuki
AU - Hackenberg, Dieter
AU - Shimamura, Masaki
AU - Nishiyama, Tomoaki
AU - Sakakibara, Keiko
AU - Tomita, Yuki
AU - Togawa, Taisuke
AU - Kunimoto, Kan
AU - Osakabe, Akihisa
AU - Suzuki, Yutaka
AU - Yamato, Katsuyuki T.
AU - Ishizaki, Kimitsune
AU - Nishihama, Ryuichi
AU - Kohchi, Takayuki
AU - Franco-Zorrilla, José M.
AU - Twell, David
AU - Berger, Frédéric
AU - Araki, Takashi
N1 - Publisher Copyright:
© 2018, The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Evolutionary mechanisms underlying innovation of cell types have remained largely unclear. In multicellular eukaryotes, the evolutionary molecular origin of sperm differentiation is unknown in most lineages. Here, we report that in algal ancestors of land plants, changes in the DNA-binding domain of the ancestor of the MYB transcription factor DUO1 enabled the recognition of a new cis-regulatory element. This event led to the differentiation of motile sperm. After neo-functionalization, DUO1 acquired sperm lineage-specific expression in the common ancestor of land plants. Subsequently the downstream network of DUO1 was rewired leading to sperm with distinct morphologies. Conjugating green algae, a sister group of land plants, accumulated mutations in the DNA-binding domain of DUO1 and lost sperm differentiation. Our findings suggest that the emergence of DUO1 was the defining event in the evolution of sperm differentiation and the varied modes of sexual reproduction in the land plant lineage.
AB - Evolutionary mechanisms underlying innovation of cell types have remained largely unclear. In multicellular eukaryotes, the evolutionary molecular origin of sperm differentiation is unknown in most lineages. Here, we report that in algal ancestors of land plants, changes in the DNA-binding domain of the ancestor of the MYB transcription factor DUO1 enabled the recognition of a new cis-regulatory element. This event led to the differentiation of motile sperm. After neo-functionalization, DUO1 acquired sperm lineage-specific expression in the common ancestor of land plants. Subsequently the downstream network of DUO1 was rewired leading to sperm with distinct morphologies. Conjugating green algae, a sister group of land plants, accumulated mutations in the DNA-binding domain of DUO1 and lost sperm differentiation. Our findings suggest that the emergence of DUO1 was the defining event in the evolution of sperm differentiation and the varied modes of sexual reproduction in the land plant lineage.
UR - http://www.scopus.com/inward/record.url?scp=85058238945&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058238945&partnerID=8YFLogxK
U2 - 10.1038/s41467-018-07728-3
DO - 10.1038/s41467-018-07728-3
M3 - Article
C2 - 30538242
AN - SCOPUS:85058238945
SN - 2041-1723
VL - 9
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5283
ER -