TY - JOUR
T1 - Transcriptional control in the mammalian liver
T2 - Liver development, perinatal repression, and zonal gene regulation
AU - Spear, B. T.
AU - Jin, L.
AU - Ramasamy, S.
AU - Dobierzewska, A.
PY - 2006/12
Y1 - 2006/12
N2 - Liver function is crucial for maintaining metabolic homeostasis in mammals. Numerous genes must be properly regulated for the liver to develop and perform a variety of activities. Several recent gene-knockout studies in mice have clarified the roles of GATA6, HNF4α, and Foxa1/Foxa2 in early stages of liver formation. After the liver forms, transcriptional changes continue to occur; during the perinatal period, certain genes such as α-fetoprotein and H19 are silenced, others are activated, and position-dependent (or zonal) regulation is established. Zhx2 was recently identified as one factor involved in postnatal repression of α-fetoprotein and other genes. Furthermore, several studies indicate that negative regulation is involved in the zonal control of glutamine synthetase. Finally, exciting new evidence indicates that signaling through the Wnt/β-catenin pathway is also involved in zonal regulation in the adult liver.
AB - Liver function is crucial for maintaining metabolic homeostasis in mammals. Numerous genes must be properly regulated for the liver to develop and perform a variety of activities. Several recent gene-knockout studies in mice have clarified the roles of GATA6, HNF4α, and Foxa1/Foxa2 in early stages of liver formation. After the liver forms, transcriptional changes continue to occur; during the perinatal period, certain genes such as α-fetoprotein and H19 are silenced, others are activated, and position-dependent (or zonal) regulation is established. Zhx2 was recently identified as one factor involved in postnatal repression of α-fetoprotein and other genes. Furthermore, several studies indicate that negative regulation is involved in the zonal control of glutamine synthetase. Finally, exciting new evidence indicates that signaling through the Wnt/β-catenin pathway is also involved in zonal regulation in the adult liver.
KW - Alpha-fetoprotein
KW - Glutamine synthetase
KW - Liver development
KW - Wnt/β-catenin
KW - Zhx2
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U2 - 10.1007/s00018-006-6258-5
DO - 10.1007/s00018-006-6258-5
M3 - Review article
C2 - 17041810
AN - SCOPUS:33846083134
SN - 1420-682X
VL - 63
SP - 2922
EP - 2938
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
IS - 24
ER -