Transferrin receptor 1 deficiency in smooth muscle cells attenuates vascular remodeling in hypertensive mice

Yoshiro Naito; Hisashi Sawada; Tetsuo Horimatsu; Masaki Ohmuraya; Masanori Asakura; Masaharu Ishihara

doi:10.1038/s41440-025-02254-4

Transferrin receptor 1 deficiency in smooth muscle cells attenuates vascular remodeling in hypertensive mice

Yoshiro Naito, Hisashi Sawada, Tetsuo Horimatsu, Masaki Ohmuraya, Masanori Asakura, Masaharu Ishihara

Research output: Contribution to journal › Article › peer-review

Abstract

Transferrin receptor 1 (TfR1), a crucial cellular iron receptor, has a variety of biological functions. We have previously reported that TfR1 abundance increases in the aortic media of hypertensive rat models. However, its role in vascular diseases remains unknown. In the present study, we generated smooth muscle cell (SMC)-specific TfR1 deficient mice and examined the impact of its deletion in mouse models of hypertension induced by angiotensin II or deoxycorticosterone acetate/salt administration. SMC-specific TfR1 deletion attenuated medial thickening and elastin fragmentation in both mouse models of hypertension. These results indicate that TfR1 in SMCs exerts a role in vascular remodeling in hypertension. (Figure presented.)

Original language	English
Pages (from-to)	2263-2268
Number of pages	6
Journal	Hypertension Research
Volume	48
Issue number	8
DOIs	https://doi.org/10.1038/s41440-025-02254-4
State	Published - Aug 2025

Bibliographical note

Publisher Copyright:
© The Author(s) 2025.

Funding

This work was supported by a Grant-in-Aid for Scientific Research (C) JSPS KAKENHI (#25460919, #16K09273, #19K07950, #22K07408) and grants from The Salt Science Research Foundation (#1544, #1641, #1826, and #2134) to Naito Y.

Funders	Funder number
Japan Society for the Promotion of Science	22K07408, 25460919, 16K09273, 19K07950
Salt Science Research Foundation	1544, 1641, 2134, 1826

Keywords

Smooth muscle cell
Transferrin receptor 1
Vascular remodeling

ASJC Scopus subject areas

Internal Medicine
Physiology
Cardiology and Cardiovascular Medicine

Access to Document

10.1038/s41440-025-02254-4

Cite this

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abstract = "Transferrin receptor 1 (TfR1), a crucial cellular iron receptor, has a variety of biological functions. We have previously reported that TfR1 abundance increases in the aortic media of hypertensive rat models. However, its role in vascular diseases remains unknown. In the present study, we generated smooth muscle cell (SMC)-specific TfR1 deficient mice and examined the impact of its deletion in mouse models of hypertension induced by angiotensin II or deoxycorticosterone acetate/salt administration. SMC-specific TfR1 deletion attenuated medial thickening and elastin fragmentation in both mouse models of hypertension. These results indicate that TfR1 in SMCs exerts a role in vascular remodeling in hypertension. (Figure presented.)",

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AU - Naito, Yoshiro

AU - Sawada, Hisashi

AU - Horimatsu, Tetsuo

AU - Ohmuraya, Masaki

AU - Asakura, Masanori

AU - Ishihara, Masaharu

N1 - Publisher Copyright: © The Author(s) 2025.

PY - 2025/8

Y1 - 2025/8

N2 - Transferrin receptor 1 (TfR1), a crucial cellular iron receptor, has a variety of biological functions. We have previously reported that TfR1 abundance increases in the aortic media of hypertensive rat models. However, its role in vascular diseases remains unknown. In the present study, we generated smooth muscle cell (SMC)-specific TfR1 deficient mice and examined the impact of its deletion in mouse models of hypertension induced by angiotensin II or deoxycorticosterone acetate/salt administration. SMC-specific TfR1 deletion attenuated medial thickening and elastin fragmentation in both mouse models of hypertension. These results indicate that TfR1 in SMCs exerts a role in vascular remodeling in hypertension. (Figure presented.)

AB - Transferrin receptor 1 (TfR1), a crucial cellular iron receptor, has a variety of biological functions. We have previously reported that TfR1 abundance increases in the aortic media of hypertensive rat models. However, its role in vascular diseases remains unknown. In the present study, we generated smooth muscle cell (SMC)-specific TfR1 deficient mice and examined the impact of its deletion in mouse models of hypertension induced by angiotensin II or deoxycorticosterone acetate/salt administration. SMC-specific TfR1 deletion attenuated medial thickening and elastin fragmentation in both mouse models of hypertension. These results indicate that TfR1 in SMCs exerts a role in vascular remodeling in hypertension. (Figure presented.)

KW - Smooth muscle cell

KW - Transferrin receptor 1

KW - Vascular remodeling

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Transferrin receptor 1 deficiency in smooth muscle cells attenuates vascular remodeling in hypertensive mice

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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