Abstract
We have studied the production of transforming growth factor (TGF) by several human tumor cell lines and their interactions with exogenously added epidermal growth factor (EGF) and insulin. TGF-like activities were present in all the conditioned media tested. The clonogenic capacity of the tumor cell lines had no correlation with the TGF-like activity production. EGF and insulin had a promoting colony-forming activity on tumor cells but this effect was not additive. Moreover, an inverse statistically significant correlation (-0.817, p<0.05) was found between the response to exogenous EGF and the EGF or TGF-α production by tumor cell lines. The EGF receptor (EGF-R) was not detected in any of the melanomas studied, nor in breast adenocarcinoma cell lines which were producers of EGF or TGF-α.
Original language | English |
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Pages (from-to) | 1245-1248 |
Number of pages | 4 |
Journal | Anticancer Research |
Volume | 9 |
Issue number | 4 |
State | Published - 1989 |
ASJC Scopus subject areas
- Oncology
- Cancer Research