Translating Animal Models of Ischemic Stroke to the Human Condition

Abhijith V. Matur, Eduardo Candelario-Jalil, Surojit Paul, Vardan T. Karamyan, Jessica D. Lee, Keith Pennypacker, Justin F. Fraser

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Ischemic stroke is a leading cause of death and disability. However, very few neuroprotective agents have shown promise for treatment of ischemic stroke in clinical trials, despite showing efficacy in many successful preclinical studies. This may be attributed, at least in part, to the incongruency between experimental animal stroke models used in preclinical studies and the manifestation of ischemic stroke in humans. Most often the human population selected for clinical trials are more diverse than the experimental model used in a preclinical study. For successful translation, it is critical to develop clinical trial designs that match the experimental animal model used in the preclinical study. This review aims to provide a comprehensive summary of commonly used animal models with clear correlates between rodent models used to study ischemic stroke and the clinical stroke pathologies with which they most closely align. By improving the correlation between preclinical studies and clinical trials, new neuroprotective agents and stroke therapies may be more accurately and efficiently identified.

Original languageEnglish
Pages (from-to)842-853
Number of pages12
JournalTranslational Stroke Research
Volume14
Issue number6
DOIs
StatePublished - Dec 2023

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

  • Animal model
  • Cerebrovascular
  • Neuroprotection
  • Preclinical testing
  • Stroke
  • Therapy

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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