Translating 'big data': Better understanding of host-pathogen interactions to control bacterial foodborne pathogens in poultry

Loïc Deblais, Dipak Kathayat, Yosra A. Helmy, Gary Closs, Gireesh Rajashekara

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Recent technological advances has led to the generation, storage, and sharing of colossal sets of information ('big data'), and the expansion of 'omics' in science. To date, genomics/metagenomics, transcriptomics, proteomics, and metabolomics are arguably the most ground breaking approaches in food and public safety. Here we review some of the recent studies of foodborne pathogens (Campylobacter spp., Salmonella spp., and Escherichia coli) in poultry using big data. Genomic/metagenomic approaches have reveal the importance of the gut microbiota in health and disease. They have also been used to identify, monitor, and understand the epidemiology of antibiotic-resistance mechanisms and provide concrete evidence about the role of poultry in human infections. Transcriptomics studies have increased our understanding of the pathophysiology and immunopathology of foodborne pathogens in poultry and have led to the identification of host-resistance mechanisms. Proteomic/metabolomic approaches have aided in identifying biomarkers and the rapid detection of low levels of foodborne pathogens. Overall, 'omics' approaches complement each other and may provide, at least in part, a solution to our current food-safety issues by facilitating the development of new rapid diagnostics, therapeutic drugs, and vaccines to control foodborne pathogens in poultry. However, at this time most 'omics' approaches still remain underutilized due to their high cost and the high level of technical skills required.

Original languageEnglish
Pages (from-to)15-35
Number of pages21
JournalAnimal Health Research Reviews
Issue number1
StatePublished - Jun 1 2020

Bibliographical note

Funding Information:
This research was supported by state and federal funds appropriated to the Ohio Agricultural Research and Development Center, The Ohio State University.

Publisher Copyright:
Copyright © Cambridge University Press 2020.


  • Campylobacter
  • Escherichia coli
  • omics
  • Salmonella
  • therapeutic targets

ASJC Scopus subject areas

  • Animal Science and Zoology


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