Translating molecular discoveries into new therapies for atherosclerosis

Daniel J. Rader, Alan Daugherty

Research output: Contribution to journalReview articlepeer-review

391 Scopus citations

Abstract

Atherosclerosis is characterized by the thickening of the arterial wall and is the primary cause of coronary artery disease and cerebrovascular disease, two of the most common causes of illness and death worldwide. Clinical trials have confirmed that certain lipoproteins and the renin-angiotensin-aldosterone system are important in the pathogenesis of atherosclerotic cardiovascular disease, and that interventions targeted towards these are beneficial. Furthermore, efforts to understand how risk factors such as high blood pressure, dysregulated blood lipids and diabetes contribute to atherosclerotic disease, as well as to understand the molecular pathogenesis of atherosclerotic plaques, are leading to new targets for therapy.

Original languageEnglish
Pages (from-to)904-913
Number of pages10
JournalNature
Volume451
Issue number7181
DOIs
StatePublished - Feb 21 2008

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'Translating molecular discoveries into new therapies for atherosclerosis'. Together they form a unique fingerprint.

Cite this