Transplantation of adrenal medullary tissue to caudate nucleus using stereotactic techniques

P. L. Gildenberg, L. C. Pettigrew, R. Merrell, I. Butler, R. Conklin, J. Katz, J. DeFrance

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Stereotactic techniques were used to transplant adrenal medullary tissue to the head of the right caudate nucleus in 12 patients with Parkinson's disease. No significant lasting complications were seen. All patients had an initial improvement. 11 of the 12 patients remain improved over their preoperative condition after 6-18 months, 3 with good results and 9 with only modest improvement. At 6 months, the mean Schwab and England score had improved from 59.2 ± 18.8 preoperatively to 75.8 ± 15.1 (p ≤ 0.01) and the mean Hoehn and Yahr scale had improved from 3.42 ± 0.90 to 2.92 ± 0.63 (p ≤ 0.01).

Original languageEnglish
Pages (from-to)268-271
Number of pages4
JournalStereotactic and Functional Neurosurgery
StatePublished - 1990


  • Parkinson's disease
  • adrenal tissue
  • stereotaxy
  • transplantation

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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