Transplantation of adrenal medullary tissue to caudate nucleus using stereotactic techniques

P. L. Gildenberg; L. C. Pettigrew; R. Merrell; I. Butler; R. Conklin; J. Katz; J. DeFrance

doi:10.1159/000100221

Transplantation of adrenal medullary tissue to caudate nucleus using stereotactic techniques

P. L. Gildenberg, L. C. Pettigrew, R. Merrell, I. Butler, R. Conklin, J. Katz, J. DeFrance

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9 Scopus citations

Abstract

Stereotactic techniques were used to transplant adrenal medullary tissue to the head of the right caudate nucleus in 12 patients with Parkinson's disease. No significant lasting complications were seen. All patients had an initial improvement. 11 of the 12 patients remain improved over their preoperative condition after 6-18 months, 3 with good results and 9 with only modest improvement. At 6 months, the mean Schwab and England score had improved from 59.2 ± 18.8 preoperatively to 75.8 ± 15.1 (p ≤ 0.01) and the mean Hoehn and Yahr scale had improved from 3.42 ± 0.90 to 2.92 ± 0.63 (p ≤ 0.01).

Original language	English
Pages (from-to)	268-271
Number of pages	4
Journal	Stereotactic and Functional Neurosurgery
Volume	54-55
DOIs	https://doi.org/10.1159/000100221
State	Published - 1990

Keywords

Parkinson's disease
adrenal tissue
stereotaxy
transplantation

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1159/000100221

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title = "Transplantation of adrenal medullary tissue to caudate nucleus using stereotactic techniques",

abstract = "Stereotactic techniques were used to transplant adrenal medullary tissue to the head of the right caudate nucleus in 12 patients with Parkinson's disease. No significant lasting complications were seen. All patients had an initial improvement. 11 of the 12 patients remain improved over their preoperative condition after 6-18 months, 3 with good results and 9 with only modest improvement. At 6 months, the mean Schwab and England score had improved from 59.2 ± 18.8 preoperatively to 75.8 ± 15.1 (p ≤ 0.01) and the mean Hoehn and Yahr scale had improved from 3.42 ± 0.90 to 2.92 ± 0.63 (p ≤ 0.01).",

keywords = "Parkinson's disease, adrenal tissue, stereotaxy, transplantation",

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year = "1990",

doi = "10.1159/000100221",

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pages = "268--271",

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T1 - Transplantation of adrenal medullary tissue to caudate nucleus using stereotactic techniques

AU - Gildenberg, P. L.

AU - Pettigrew, L. C.

AU - Merrell, R.

AU - Butler, I.

AU - Conklin, R.

AU - Katz, J.

AU - DeFrance, J.

PY - 1990

Y1 - 1990

N2 - Stereotactic techniques were used to transplant adrenal medullary tissue to the head of the right caudate nucleus in 12 patients with Parkinson's disease. No significant lasting complications were seen. All patients had an initial improvement. 11 of the 12 patients remain improved over their preoperative condition after 6-18 months, 3 with good results and 9 with only modest improvement. At 6 months, the mean Schwab and England score had improved from 59.2 ± 18.8 preoperatively to 75.8 ± 15.1 (p ≤ 0.01) and the mean Hoehn and Yahr scale had improved from 3.42 ± 0.90 to 2.92 ± 0.63 (p ≤ 0.01).

AB - Stereotactic techniques were used to transplant adrenal medullary tissue to the head of the right caudate nucleus in 12 patients with Parkinson's disease. No significant lasting complications were seen. All patients had an initial improvement. 11 of the 12 patients remain improved over their preoperative condition after 6-18 months, 3 with good results and 9 with only modest improvement. At 6 months, the mean Schwab and England score had improved from 59.2 ± 18.8 preoperatively to 75.8 ± 15.1 (p ≤ 0.01) and the mean Hoehn and Yahr scale had improved from 3.42 ± 0.90 to 2.92 ± 0.63 (p ≤ 0.01).

KW - Parkinson's disease

KW - adrenal tissue

KW - stereotaxy

KW - transplantation

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JO - Stereotactic and Functional Neurosurgery

JF - Stereotactic and Functional Neurosurgery

ER -

Transplantation of adrenal medullary tissue to caudate nucleus using stereotactic techniques

Abstract

Keywords

ASJC Scopus subject areas

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