Transplantation of male mouse submaxillary gland increase survival of axotomized basal forebrain neurons

J. E. Springer, T. J. Collier, J. R. Sladek, R. Loy

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Transaction of the fimbria‐fornix results in a loss of magnocellular neurons in the medial septum and vertical limb of the diagonal band (MS/VDB), possibly due to the deprivation of a retrogradely transported trophic substance, such as nerve growth factor (NGF), derived from the hippocampal formation. We have, utilized a transplantation model in which grafts of NGF‐rich male mouse submaxillary gland were placed in the lateral ventricle adjacent to the MS/VDB of rats with transactions of the fimbria‐fornix. At 2‐4 weeks following transection, animals with grafted submaxillary glands exhibited enhanced survival of MS/VDB neurons, which stained positive for acetycholinesterase and were immunoreactive for the NGF receptor. These experiments demonstrate that grafts of male mouse submaxillary gland can facilitate the survival of axotomized MS/VDB cholinergic neurons and may therefore prove beneficial in promoting regeneration of damaged neural systems.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalJournal of Neuroscience Research
Issue number3
StatePublished - Mar 1988


  • cholinergic neurons
  • hippocampus
  • medial septum
  • nerve growth factor
  • trophic factors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience


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