Treating Disease Mechanisms in Patients With Heart Failure and Diabetes Mellitus

Amanda Trang, David Aguilar

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Purpose of Review: Diabetes and heart failure commonly coexist and portend worsened prognosis than either disease alone. We explore mechanisms that may serve as potential treatment targets and review the effects of various contemporary glucose-lowering agents on heart failure outcomes. Recent Findings: Promising data has emerged on sodium-glucose cotransporter 2 (SLGT2) inhibitors as the first class of agents to improve cardiovascular mortality and heart failure outcomes in diabetic individuals both with and without established heart failure. Summary: Poor glycemic control is linked to worse heart failure outcomes; however, targeting glycemic control alone has not been sufficient. Furthermore, multiple commonly used antihyperglycemic agents may lead to adverse heart failure effects. SGLT2 inhibitors target multiple mechanisms implicated in diabetes and heart failure and may play a promising role in primary prevention of heart failure and in treatment of individuals with diabetes and established heart failure.

Original languageEnglish
Pages (from-to)445-453
Number of pages9
JournalCurrent Heart Failure Reports
Issue number6
StatePublished - Dec 1 2017

Bibliographical note

Publisher Copyright:
© 2017, Springer Science+Business Media, LLC.


  • Diabetes
  • Heart failure
  • Sodium-glucose cotransporter 2

ASJC Scopus subject areas

  • Emergency Medicine
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


Dive into the research topics of 'Treating Disease Mechanisms in Patients With Heart Failure and Diabetes Mellitus'. Together they form a unique fingerprint.

Cite this