Abstract
Background: Approximately 16.5% of U.S. young adults have a cannabis use disorder (CUD) and are at risk for negative outcomes. Treatment can reduce cannabis use, but young adults are less likely to seek help than older adults. Peer Network Counseling-txt (PNC-txt) is a brief, text-delivered, Motivational Interviewing-informed substance use intervention focusing on peer relations and activity spaces as mechanisms for behavioral change. PNC-txt has shown evidence of reducing tobacco and cannabis use with adolescents and young adults, but it has not been tested in the context of legal cannabis use. The current randomized controlled trial sought to expand the evidence regarding the context of PNC-txt effects, comparing one state in which cannabis is legal (Colorado) and one state in which it is not (Tennessee). We hypothesized that participants randomized to PNC-txt would show significant reductions in cannabis use compared to controls, with larger reductions for females and those in Colorado, and that peer relations and activity space would mediate effects. Methods: One thousand, seventy eight 18–25 year olds (CO: 551; TN: 527) who met screening criteria for CUD and biologically-verified cannabis use were randomly assigned to PNC-txt or waitlist control condition. Every other day for 4 weeks, participants assigned to PNC-txt received pre-programmed text conversations, tailored via data from the baseline assessment. Self-report and biological indicators of cannabis use were measured at 1-, 3-, and 6-months. Discussion: Data analysis is underway. Results will provide evidence regarding whether, and how, PNC-txt reduces cannabis use in young adults with CUD. Trial registration: This trial was prospectively registered on September 28, 2020 with ClinicalTrials.gov (NCT04567394).
| Original language | English |
|---|---|
| Article number | 107635 |
| Journal | Contemporary Clinical Trials |
| Volume | 144 |
| DOIs | |
| State | Published - Sep 2024 |
Bibliographical note
Publisher Copyright:© 2024
Funding
This study is being funded by a grant from the National Institute on Drug Abuse, grant number R01 DA044206-01A1, to Michael J. Mason and J. Douglas Coatsworth. This trial is funded by the National Institute on Drug Abuse (1 R01 DA044206-01A1) and is registered with ClinicalTrials.gov ( NCT04567394 ). The Institutional Review Board (IRB) at The University of Tennessee (UT) approved all components of the study; Colorado State University (CSU) has signed an IRB Reliance Agreement with UT, thereby utilizing a single IRB approval for this study. As of this writing, we have completed recruitment and data collection, and are cleaning data and conducting analyses.
| Funders | Funder number |
|---|---|
| Author National Institute on Drug Abuse DA031791 Mark J Ferris National Institute on Drug Abuse DA006634 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA026117 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA028162 Elizabeth G Pitts National Institute of General Medical Sciences GM102773 Elizabeth G Pitts Peter McManus Charitable Trust Mark J Ferris National Institute on Drug Abuse | NCT04567394, R01 DA044206-01A1 |
Keywords
- Cannabis use disorder treatment
- Mobile health
- Protocol
- Text-delivered intervention
ASJC Scopus subject areas
- Pharmacology (medical)
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