Purpose: Recent studies confirm the utility of speechlanguage intervention in primary progressive aphasia (PPA); however, long-term outcomes, ideal dosage parameters, and relative benefits of intervention across clinical variants warrant additional investigation. The purpose of this study was to determine whether naming treatment affords significant, lasting, and generalized improvement for individuals with semantic and logopenic PPA and whether dosage manipulations significantly affect treatment outcomes. Method: Eighteen individuals with PPA (9 semantic and 9 logopenic variant) underwent lexical retrieval treatment designed to leverage spared cognitive-linguistic domains and develop self-cueing strategies to promote naming. One group (n = 10) underwent once-weekly treatment sessions, and the other group (n = 8) received the same treatment with 2 sessions per week and an additional “booster” treatment phase at 3 months post-treatment. Performance on trained and untrained targets/tasks was measured immediately after treatment and at 3, 6, and 12 months post-treatment. Results: Outcomes from the full cohort of individuals with PPA showed significantly improved naming of trained items immediately post-treatment and at all follow-up assessments through 1 year. Generalized improvement on untrained items was significant up to 6 months post-treatment. The positive response to treatment was comparable regardless of session frequency or inclusion of a booster phase. Outcomes were comparable across PPA subtypes, as was maintenance of gains over the post-treatment period. Conclusion: This study documents positive naming treatment outcomes for a group of individuals with PPA, demonstrating strong direct treatment effects, maintenance of gains up to 1 year post-treatment, and generalization to untrained items. Lexical retrieval treatment, in conjunction with daily home practice, had a strong positive effect that did not require more than 1 clinician-directed treatment session per week. Findings confirm that strategic training designed to capitalize on spared cognitive-linguistic abilities results in significant and lasting improvement, despite ongoing disease progression, in PPA.
|Number of pages
|Journal of Speech, Language, and Hearing Research
|Published - Aug 2019
Bibliographical noteFunding Information:
This work was funded by the National Institute on Deafness and Other Communication Disorders (NIDCD) Grants F32DC010945, R01 DC016291 and R03 DC013403 (awarded to M. H.), National Institute of Neurological Disorders and Stroke Grant R01 NS050915 and NIDCD Grant K24 DC015544 (awarded to M. G. T.), National Institute on Aging Grants P01 AG019724 and P50 AG023501 (awarded to B. M.), NIDCD Grant R01 DC007647 (awarded to P. B.) and the Darrell K Royal Research Fund for Alzheimer’s Disease (awarded to M. H.). We
This work was funded by the National Institute on Deafness and Other Communication Disorders (NIDCD) Grants F32DC010945, R01 DC016291 and R03 DC013403 (awarded to M. H.), National Institute of Neurological Disorders and Stroke Grant R01 NS050915 and NIDCD Grant K24 DC015544 (awarded to M. G. T.), National Institute on Aging Grants P01 AG019724 and P50 AG023501 (awarded to B. M.), NIDCD Grant R01 DC007647 (awarded to P. B.) and the Darrell K Royal Research Fund for Alzheimer?s Disease (awarded to M. H.). We thank the members of the University of Texas, Austin Aphasia Research and Treatment Lab and the University of California, San Francisco Memory and Aging Center who contributed to all aspects of patient care. Special thanks to Mithra Sathishkumar, who contributed to magnetic resonance imaging analysis; Lindsey Wineholt and Miranda Babiak, who aided with patient assessment and data management; Holly Hinshelwood and Ariane Welch, who contributed to data management; and Greg Hixon for statistical consultation. Finally, we wish to thank all of our participants with primary progressive aphasia for the time and effort that they have devoted to our research.
© 2019 American Speech-Language-Hearing Association.
ASJC Scopus subject areas
- Language and Linguistics
- Linguistics and Language
- Speech and Hearing