Treatment modality and outcomes in larynx cancer patients: A sex-based evaluation

Hong Li, Eva Yujia Li, Alexandra Eva Kejner

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Background: To evaluate the differences in treatment modality and outcomes between male and female patients with laryngeal squamous cell carcinoma (SCC) in the United States. Methods: Data were extracted from the Surveillance, Epidemiology, and End Results Database for patients with laryngeal SCC (2004-2013). Overall survival (OS), disease specific survival (DSS), and multivariate analyses were conducted. Results: Among women, supraglottic cancers were the most prevalent (61.2%); whereas the majority of men developed glottic cancers (64.2%; P <.001). Women with T4 disease were more likely to undergo primary radiation (56.8% vs 45.3%; P <.001) and less likely to undergo open surgery were than men (37.1% vs 48.2%; P <.001). Women had significantly better OS in glottic and supraglottic cancers, and comparable survival in subglottic cancer. Sex remained an independent prognostic factor for both DSS and OS. Conclusion: Sex is an independent prognostic factor for DSS and OS in patients with laryngeal SCC.

Original languageEnglish
Pages (from-to)3764-3774
Number of pages11
JournalHead and Neck
Issue number11
StatePublished - Nov 1 2019

Bibliographical note

Publisher Copyright:
© 2019 Wiley Periodicals, Inc.


  • disparity
  • gender
  • larynx cancer
  • larynx cancer treatment
  • sex

ASJC Scopus subject areas

  • Otorhinolaryngology


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