Abstract
Background: To evaluate the differences in treatment modality and outcomes between male and female patients with laryngeal squamous cell carcinoma (SCC) in the United States. Methods: Data were extracted from the Surveillance, Epidemiology, and End Results Database for patients with laryngeal SCC (2004-2013). Overall survival (OS), disease specific survival (DSS), and multivariate analyses were conducted. Results: Among women, supraglottic cancers were the most prevalent (61.2%); whereas the majority of men developed glottic cancers (64.2%; P <.001). Women with T4 disease were more likely to undergo primary radiation (56.8% vs 45.3%; P <.001) and less likely to undergo open surgery were than men (37.1% vs 48.2%; P <.001). Women had significantly better OS in glottic and supraglottic cancers, and comparable survival in subglottic cancer. Sex remained an independent prognostic factor for both DSS and OS. Conclusion: Sex is an independent prognostic factor for DSS and OS in patients with laryngeal SCC.
Original language | English |
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Pages (from-to) | 3764-3774 |
Number of pages | 11 |
Journal | Head and Neck |
Volume | 41 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1 2019 |
Bibliographical note
Publisher Copyright:© 2019 Wiley Periodicals, Inc.
Keywords
- disparity
- gender
- larynx cancer
- larynx cancer treatment
- sex
ASJC Scopus subject areas
- Otorhinolaryngology