Treatment of bone, joint, and soft-tissue infections with oral ciprofloxacin

R. N. Greenberg, D. J. Kennedy, P. M. Reilly, K. L. Luppen, W. J. Weinandt, M. R. Bollinger, F. Aguirre, F. Kodesch, A. M. Saeed

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

We treated 52 patients with orally administered ciprofloxacin. In this study of 34 men and 18 women who completed therapy and who could be evaluated, there were 29 patients with nonhematogenous osteomyelitis, 20 patients with skin or soft-tissue infections, and 3 patients with joint infections. During the study, 92 isolates of pathogenic facultative aerobic bacteria, including 37 members of the family Enterobacteriaceae, 30 Staphylococcus aureus isolates, and 21 Pseudomonas aeruginosa isolates, were recovered, and 88 (96%) of the isolates were found to be susceptible to ciprofloxacin. Of the 29 patients with osteomyelitis, 14 have not experienced relapse after a follow-up of at least 1 year. Overall, 61% of infections were resolved, as judged by both clinical and microbiological criteria, during therapy. One patient developed Streptococcus salivarius sepsis during ciprofloxacin therapy, and one patient developed a rash which required discontinuation of ciprofloxacin. Otherwise, there were no serious reactions or complications.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume31
Issue number2
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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