Treatment of localized aggressive periodontitis alters local host immunoinflammatory profiles: A long-term evaluation

Luciana S. Branco-de-Almeida, Yenisel Cruz-Almeida, Yandy Gonzalez-Marrero, Rachad Kudsi, Izabel C.V. de Oliveira, Bogdan Dolia, Hong Huang, Ikramuddin Aukhil, Peter Harrison, Luciana M. Shaddox

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Aim: To evaluate the local immunoinflammatory profiles in localized aggressive periodontitis patients (LAP) before and after periodontal treatment and maintenance. Methods: Sixty-six African-Americans with LAP (7–21 years old) were included. After periodontal examination, all patients received periodontal treatment with mechanical debridement plus systemic amoxicillin/metronidazole for 7 days. Gingival crevicular fluid was collected from diseased and healthy sites at baseline and 3, 6, 12, and 24 months following treatment. Levels of 16 inflammatory/bone resorption markers were determined using Milliplex®. Univariate and correlation analyses were performed among all parameters/biomarkers. Discriminant analyses (DA) evaluated profile differences between LAP diseased and healthy sites at each time point as compared to the baseline. Results: Reductions in the clinical parameters (except for visible plaque) were observed at all time points compared to the baseline. Levels of IL-12p70, IL-2, IL-6, MIP-1α, RANKL, and OPG were reduced after treatment, and several cytokines/chemokines were correlated with clinical parameters reductions. DA showed that differences in the immunoinflammatory profiles between LAP diseased and healthy sites decreased after periodontal treatment compared to the baseline. Conclusions: Periodontal treatment modified the local immunoinflammatory profile of LAP sites in the long term, as suggested by changes in biomarkers from baseline, along with clinical stability of the disease. ( number, NCT01330719).

Original languageEnglish
Pages (from-to)237-248
Number of pages12
JournalJournal of Clinical Periodontology
Issue number2
StatePublished - Feb 2021

Bibliographical note

Publisher Copyright:
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd


  • aggressive periodontitis
  • gingival crevicular fluid
  • inflammation
  • long-term effects
  • therapy

ASJC Scopus subject areas

  • Periodontics


Dive into the research topics of 'Treatment of localized aggressive periodontitis alters local host immunoinflammatory profiles: A long-term evaluation'. Together they form a unique fingerprint.

Cite this