Treatment of localized aggressive periodontitis alters local host immunoinflammatory profiles: A long-term evaluation

Luciana S. Branco-de-Almeida, Yenisel Cruz-Almeida, Yandy Gonzalez-Marrero, Rachad Kudsi, Izabel C.V. de Oliveira, Bogdan Dolia, Hong Huang, Ikramuddin Aukhil, Peter Harrison, Luciana M. Shaddox

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Aim: To evaluate the local immunoinflammatory profiles in localized aggressive periodontitis patients (LAP) before and after periodontal treatment and maintenance. Methods: Sixty-six African-Americans with LAP (7–21 years old) were included. After periodontal examination, all patients received periodontal treatment with mechanical debridement plus systemic amoxicillin/metronidazole for 7 days. Gingival crevicular fluid was collected from diseased and healthy sites at baseline and 3, 6, 12, and 24 months following treatment. Levels of 16 inflammatory/bone resorption markers were determined using Milliplex®. Univariate and correlation analyses were performed among all parameters/biomarkers. Discriminant analyses (DA) evaluated profile differences between LAP diseased and healthy sites at each time point as compared to the baseline. Results: Reductions in the clinical parameters (except for visible plaque) were observed at all time points compared to the baseline. Levels of IL-12p70, IL-2, IL-6, MIP-1α, RANKL, and OPG were reduced after treatment, and several cytokines/chemokines were correlated with clinical parameters reductions. DA showed that differences in the immunoinflammatory profiles between LAP diseased and healthy sites decreased after periodontal treatment compared to the baseline. Conclusions: Periodontal treatment modified the local immunoinflammatory profile of LAP sites in the long term, as suggested by changes in biomarkers from baseline, along with clinical stability of the disease. (Clinicaltrials.gov number, NCT01330719).

Original languageEnglish
JournalJournal of Clinical Periodontology
DOIs
StateAccepted/In press - 2020

Bibliographical note

Funding Information:
We would like to thank the National Institutes of Health/ National Institute of Dental and Craniofacial Research for the financial support/fellowship (NIH/NIDCR; grants #R01DE019456 and #R90DE22530‐4). The authors are also grateful to dentists and all the staff from the health departments of Leon County, Duval County, and from the University of Florida College of Dentistry (Florida, USA). The authors declare that there are no conflicts of interest with respect to the authorship and/or publication of this article.

Publisher Copyright:
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Keywords

  • aggressive periodontitis
  • gingival crevicular fluid
  • inflammation
  • long-term effects
  • therapy

ASJC Scopus subject areas

  • Periodontics

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