Treatment of mice with methamphetamine produces cell loss in the substantia nigra

Patricia K. Sonsalla; Nina D. Jochnowitz; Gail D. Zeevalk; Jo A. Oostveen; Edward D. Hall

doi:10.1016/0006-8993(96)00995-X

Treatment of mice with methamphetamine produces cell loss in the substantia nigra

Patricia K. Sonsalla, Nina D. Jochnowitz, Gail D. Zeevalk, Jo A. Oostveen, Edward D. Hall

Neuroscience

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Abstract

Studies were conducted to determine if treatment of mice with methamphetamine (METH) would produce a loss of dopaminergic cells in the substantia nigra. The number of TH⁺/Nissl-stained cells was significantly decreased in both Swiss-Webster (S-W) and C57bl mice (approx. cell loss of 40% and 45%, respectively) 5-8 days after treatment with METH. In these same mice there was a corresponding decrease in neostriatal dopamine (DA) content (90% and 92%, respectively). In parallel studies, treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produced similar neuropathological effects. The finding that nigral cell loss occurs after METH treatment indicates that the METH-treated mouse may be a very relevant model of Parkinson's disease (PD).

Original language	English
Pages (from-to)	172-175
Number of pages	4
Journal	Brain Research
Volume	738
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(96)00995-X
State	Published - Oct 28 1996

Keywords

MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
animal model of Parkinson's disease
dopaminergic neurotoxicity
methamphetamine
mice
nigral cell loss
substantia nigra neuropathology

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Treatment of mice with methamphetamine produces cell loss in the substantia nigra",

abstract = "Studies were conducted to determine if treatment of mice with methamphetamine (METH) would produce a loss of dopaminergic cells in the substantia nigra. The number of TH+/Nissl-stained cells was significantly decreased in both Swiss-Webster (S-W) and C57bl mice (approx. cell loss of 40% and 45%, respectively) 5-8 days after treatment with METH. In these same mice there was a corresponding decrease in neostriatal dopamine (DA) content (90% and 92%, respectively). In parallel studies, treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produced similar neuropathological effects. The finding that nigral cell loss occurs after METH treatment indicates that the METH-treated mouse may be a very relevant model of Parkinson's disease (PD).",

keywords = "MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), animal model of Parkinson's disease, dopaminergic neurotoxicity, methamphetamine, mice, nigral cell loss, substantia nigra neuropathology",

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AU - Sonsalla, Patricia K.

AU - Jochnowitz, Nina D.

AU - Zeevalk, Gail D.

AU - Oostveen, Jo A.

AU - Hall, Edward D.

PY - 1996/10/28

Y1 - 1996/10/28

N2 - Studies were conducted to determine if treatment of mice with methamphetamine (METH) would produce a loss of dopaminergic cells in the substantia nigra. The number of TH+/Nissl-stained cells was significantly decreased in both Swiss-Webster (S-W) and C57bl mice (approx. cell loss of 40% and 45%, respectively) 5-8 days after treatment with METH. In these same mice there was a corresponding decrease in neostriatal dopamine (DA) content (90% and 92%, respectively). In parallel studies, treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produced similar neuropathological effects. The finding that nigral cell loss occurs after METH treatment indicates that the METH-treated mouse may be a very relevant model of Parkinson's disease (PD).

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Treatment of mice with methamphetamine produces cell loss in the substantia nigra

Abstract

Keywords

ASJC Scopus subject areas

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