Treatment options in sulfamethoxazole- trimethoprim-induced thrombocytopenic purpura

Annie Herrington, Asif Mahmood, Rolando Berger

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We describe two female patients who had severe sulfamethoxazole- trimethoprim-induced thrombocytopenic purpura. One case occurred shortly after initiating therapy, whereas the other began on the seventh day of treatment. Both patients presented a platelet count below 5,000/µL, extensive purpura, and significant vaginal bleeding. Treatment with systemic corticosteroids resulted in rapid resolution of the thrombocytopenia in the first patient, but had no immediate effect in the other. High- dose intravenous immunoglobulin was effective in correcting the thrombocytopenia in this second instance. Both patients were discharged with a tapering 4-week course of oral prednisone and have remained well since.

Original languageEnglish
Pages (from-to)948-950
Number of pages3
JournalSouthern Medical Journal
Issue number9
StatePublished - Sep 1994

ASJC Scopus subject areas

  • Medicine (all)


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