TY - JOUR
T1 - Trends in sex differences in neurodevelopmental outcomes among extremely preterm infants
AU - Boghossian, Nansi S.
AU - Mack, Nicole
AU - Bell, Edward F.
AU - Tan, Sylvia
AU - Stoll, Barbara
AU - Rysavy, Matthew
AU - Ambalavanan, Namasivayam
AU - Tyson, Jon E.
AU - Das, Abhik
AU - Hintz, Susan R.
AU - Jobe, Alan H.
AU - Caplan, Michael S.
AU - Polin, Richard A.
AU - Oh, William
AU - Keszler, Martin
AU - Laptook, Abbot R.
AU - Vohr, Betty R.
AU - Hensman, Angelita M.
AU - Burke, Robert T.
AU - Stephens, Bonnie E.
AU - Yatchmink, Yvette
AU - Alksninis, Barbara
AU - Basso, Kristin
AU - Vieira, Elisa
AU - Keszler, Lenore
AU - Knoll, Andrea
AU - Leach, Teresa M.
AU - Leonard, Martha R.
AU - Noel, Lucy
AU - Pierre, Lucille St
AU - Vogt, Rachel A.
AU - Watson, Victoria E.
AU - Hibbs, Anna Maria
AU - Fanaroff, Avroy A.
AU - Wilson-Costello, Deanne E.
AU - Newman, Nancy S.
AU - Siner, Bonnie S.
AU - Williams, Angelia
AU - Roth, Elizabeth
AU - Truog, William
AU - Kilbride, Howard
AU - Parimi, Prabhu
AU - Gauldin, Cheri
AU - Scott, Allie
AU - Johnson, Kathy
AU - Gaetano, Lisa
AU - Merhar, Stephanie L.
AU - Poindexter, Brenda B.
AU - Goldstein, Ricki F.
AU - Bada, Henrietta S.
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2024
Y1 - 2024
N2 - Objective: To examine whether changes in survival without moderate or severe neurodevelopmental impairment (NDI) at 18-26 months' corrected age from 1999 to 2018 differed between male and female infants. Design: This retrospective cohort study used data from the NICHD Neonatal Research Network hospitals. Robust Poisson regression models were used to estimate adjusted relative risks (aRRs) and 95% CIs for survival without moderate or severe NDI between males and females. Interactions between sex and time were assessed to evaluate temporal differences in the outcome by sex. Variables adjusted for included centre, maternal age, ethnicity/race, gestational age and small for gestational age. Patients: Inborn infants with gestational age of 22-26 weeks at NICHD Neonatal Research Network hospitals from 1999 to 2018. Main outcome measure: Change over time in survival without moderate or severe NDI at 18-26 months' corrected age between male and female infants. Results: Of 26 307 infants, 13 045 (49.6%) were male. Survival without moderate or severe NDI declined for both sexes over time, from 32.9% to 30.6% for males and from 47.4% to 40.0% for females, between 1999-2003 and 2014-2018. Males were less likely than females to survive without moderate or severe NDI (aRR=0.80; 95% CI 0.78 to 0.83). Changes in survival without moderate or severe NDI did not differ between males and females. Conclusion: There were no differential changes in survival without moderate or severe NDI between male and female infants.
AB - Objective: To examine whether changes in survival without moderate or severe neurodevelopmental impairment (NDI) at 18-26 months' corrected age from 1999 to 2018 differed between male and female infants. Design: This retrospective cohort study used data from the NICHD Neonatal Research Network hospitals. Robust Poisson regression models were used to estimate adjusted relative risks (aRRs) and 95% CIs for survival without moderate or severe NDI between males and females. Interactions between sex and time were assessed to evaluate temporal differences in the outcome by sex. Variables adjusted for included centre, maternal age, ethnicity/race, gestational age and small for gestational age. Patients: Inborn infants with gestational age of 22-26 weeks at NICHD Neonatal Research Network hospitals from 1999 to 2018. Main outcome measure: Change over time in survival without moderate or severe NDI at 18-26 months' corrected age between male and female infants. Results: Of 26 307 infants, 13 045 (49.6%) were male. Survival without moderate or severe NDI declined for both sexes over time, from 32.9% to 30.6% for males and from 47.4% to 40.0% for females, between 1999-2003 and 2014-2018. Males were less likely than females to survive without moderate or severe NDI (aRR=0.80; 95% CI 0.78 to 0.83). Changes in survival without moderate or severe NDI did not differ between males and females. Conclusion: There were no differential changes in survival without moderate or severe NDI between male and female infants.
KW - Epidemiology
KW - Infant Development
KW - Neonatology
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UR - http://www.scopus.com/inward/citedby.url?scp=85204945782&partnerID=8YFLogxK
U2 - 10.1136/archdischild-2024-327239
DO - 10.1136/archdischild-2024-327239
M3 - Article
C2 - 39288987
AN - SCOPUS:85204945782
SN - 1359-2998
JO - Archives of Disease in Childhood: Fetal and Neonatal Edition
JF - Archives of Disease in Childhood: Fetal and Neonatal Edition
M1 - fetalneonatal-2024-327239
ER -