Abstract
Objective: To examine whether changes in survival without moderate or severe neurodevelopmental impairment (NDI) at 18-26 months' corrected age from 1999 to 2018 differed between male and female infants. Design: This retrospective cohort study used data from the NICHD Neonatal Research Network hospitals. Robust Poisson regression models were used to estimate adjusted relative risks (aRRs) and 95% CIs for survival without moderate or severe NDI between males and females. Interactions between sex and time were assessed to evaluate temporal differences in the outcome by sex. Variables adjusted for included centre, maternal age, ethnicity/race, gestational age and small for gestational age. Patients: Inborn infants with gestational age of 22-26 weeks at NICHD Neonatal Research Network hospitals from 1999 to 2018. Main outcome measure: Change over time in survival without moderate or severe NDI at 18-26 months' corrected age between male and female infants. Results: Of 26 307 infants, 13 045 (49.6%) were male. Survival without moderate or severe NDI declined for both sexes over time, from 32.9% to 30.6% for males and from 47.4% to 40.0% for females, between 1999-2003 and 2014-2018. Males were less likely than females to survive without moderate or severe NDI (aRR=0.80; 95% CI 0.78 to 0.83). Changes in survival without moderate or severe NDI did not differ between males and females. Conclusion: There were no differential changes in survival without moderate or severe NDI between male and female infants.
| Original language | English |
|---|---|
| Article number | fetalneonatal-2024-327239 |
| Journal | Archives of Disease in Childhood: Fetal and Neonatal Edition |
| DOIs | |
| State | Accepted/In press - 2024 |
Bibliographical note
Publisher Copyright:© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.
Funding
The National Institutes of Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Center for Research Resources and the National Center for Advancing Translational Sciences provided grant support for the Neonatal Research Network’s Generic Database and Follow-up Studies through cooperative agreements. Participating NRN sites collected data and transmitted it to RTI International, the data coordinating centre (DCC) for the network, which stored, managed and analysed the data for this study. On behalf of the NRN, RTI International had full access to all of the data in the study, and with the NRN centre principal investigators, takes responsibility for the integrity of the data and accuracy of the data analysis. We are indebted to our medical and nursing colleagues and the infants and their parents who agreed to take part in this study. The investigators, in addition to those listed as authors, participated in this study. NSB is supported by the National Institute on Minority Health and Health Disparities (Award No R01MD016012). For other grant support, see the Acknowledgements section.
| Funders | Funder number |
|---|---|
| Eunice Kennedy Shriver National Institute of Child Health and Human Development | |
| National Institutes of Health (NIH) | |
| National Center for Research Resources | |
| National Center for Advancing Translational Sciences (NCATS) | |
| National Institute on Minority Health and Health Disparities (NIMHD) | R01MD016012 |
| National Institute on Minority Health and Health Disparities (NIMHD) |
Keywords
- Epidemiology
- Infant Development
- Neonatology
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology