TRH test, DST, and response to desipramine in primary degenerative dementia

T. W. McAllister; L. R. Hays

doi:10.1016/0006-3223(87)90229-0

TRH test, DST, and response to desipramine in primary degenerative dementia

T. W. McAllister, L. R. Hays

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The relationship of primary degenerative dementia (PDD) to major depressive disorder (MDD) is important clinically and theoretically. Neuroendocrine challenge strategies in PDD have focused primarily on the hypothalamic-pituitary-adrenal axis, have had varied results, and have not been coupled with assessment of response to antidepressant therapy. We studied the Thyrotropin-Releasing Hormone (TRH) test, the Dexamethasone Suppression Test (DST), and response to desipramine in 12 patients with PDD and 10 patients with MDD. The PDD patients had a high percentage of abnormal TRH tests and DSTs. This was not associated with improvement on desipramine.

Original language	English
Pages (from-to)	189-193
Number of pages	5
Journal	Biological Psychiatry
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/0006-3223(87)90229-0
State	Published - Feb 1987

Bibliographical note

Funding Information:
From the Lexington VAMC and the University of Kentucky College of Medicine, Lexington, KY. Supported in part by the University of Kentucky ColIege of Medicine PSP Fond and VA Grant 596-073-46-61 W-01. A&SS reprint requests to: T. W. McAWer, M.D., ClmW Director, ~~~yeh~ Service, Hospital of the University of Peonsyly~ia, 11th Floor Gates Pavilion, 3400 Spruce Street, ~l~ia, 19104. Received March 24, 1986; revised July 14, 1986.

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Biological Psychiatry

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title = "TRH test, DST, and response to desipramine in primary degenerative dementia",

abstract = "The relationship of primary degenerative dementia (PDD) to major depressive disorder (MDD) is important clinically and theoretically. Neuroendocrine challenge strategies in PDD have focused primarily on the hypothalamic-pituitary-adrenal axis, have had varied results, and have not been coupled with assessment of response to antidepressant therapy. We studied the Thyrotropin-Releasing Hormone (TRH) test, the Dexamethasone Suppression Test (DST), and response to desipramine in 12 patients with PDD and 10 patients with MDD. The PDD patients had a high percentage of abnormal TRH tests and DSTs. This was not associated with improvement on desipramine.",

author = "McAllister, {T. W.} and Hays, {L. R.}",

note = "Funding Information: From the Lexington VAMC and the University of Kentucky College of Medicine, Lexington, KY. Supported in part by the University of Kentucky ColIege of Medicine PSP Fond and VA Grant 596-073-46-61 W-01. A&SS reprint requests to: T. W. McAWer, M.D., ClmW Director, ~~~yeh~ Service, Hospital of the University of Peonsyly~ia, 11th Floor Gates Pavilion, 3400 Spruce Street, ~l~ia, 19104. Received March 24, 1986; revised July 14, 1986.",

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AU - Hays, L. R.

N1 - Funding Information: From the Lexington VAMC and the University of Kentucky College of Medicine, Lexington, KY. Supported in part by the University of Kentucky ColIege of Medicine PSP Fond and VA Grant 596-073-46-61 W-01. A&SS reprint requests to: T. W. McAWer, M.D., ClmW Director, ~~~yeh~ Service, Hospital of the University of Peonsyly~ia, 11th Floor Gates Pavilion, 3400 Spruce Street, ~l~ia, 19104. Received March 24, 1986; revised July 14, 1986.

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N2 - The relationship of primary degenerative dementia (PDD) to major depressive disorder (MDD) is important clinically and theoretically. Neuroendocrine challenge strategies in PDD have focused primarily on the hypothalamic-pituitary-adrenal axis, have had varied results, and have not been coupled with assessment of response to antidepressant therapy. We studied the Thyrotropin-Releasing Hormone (TRH) test, the Dexamethasone Suppression Test (DST), and response to desipramine in 12 patients with PDD and 10 patients with MDD. The PDD patients had a high percentage of abnormal TRH tests and DSTs. This was not associated with improvement on desipramine.

AB - The relationship of primary degenerative dementia (PDD) to major depressive disorder (MDD) is important clinically and theoretically. Neuroendocrine challenge strategies in PDD have focused primarily on the hypothalamic-pituitary-adrenal axis, have had varied results, and have not been coupled with assessment of response to antidepressant therapy. We studied the Thyrotropin-Releasing Hormone (TRH) test, the Dexamethasone Suppression Test (DST), and response to desipramine in 12 patients with PDD and 10 patients with MDD. The PDD patients had a high percentage of abnormal TRH tests and DSTs. This was not associated with improvement on desipramine.

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JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 2

ER -

TRH test, DST, and response to desipramine in primary degenerative dementia

Abstract

Bibliographical note

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