TRH test, DST, and response to desipramine in primary degenerative dementia

T. W. McAllister, L. R. Hays

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The relationship of primary degenerative dementia (PDD) to major depressive disorder (MDD) is important clinically and theoretically. Neuroendocrine challenge strategies in PDD have focused primarily on the hypothalamic-pituitary-adrenal axis, have had varied results, and have not been coupled with assessment of response to antidepressant therapy. We studied the Thyrotropin-Releasing Hormone (TRH) test, the Dexamethasone Suppression Test (DST), and response to desipramine in 12 patients with PDD and 10 patients with MDD. The PDD patients had a high percentage of abnormal TRH tests and DSTs. This was not associated with improvement on desipramine.

Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalBiological Psychiatry
Issue number2
StatePublished - Feb 1987

Bibliographical note

Funding Information:
From the Lexington VAMC and the University of Kentucky College of Medicine, Lexington, KY. Supported in part by the University of Kentucky ColIege of Medicine PSP Fond and VA Grant 596-073-46-61 W-01. A&SS reprint requests to: T. W. McAWer, M.D., ClmW Director, ~~~yeh~ Service, Hospital of the University of Peonsyly~ia, 11th Floor Gates Pavilion, 3400 Spruce Street, ~l~ia, 19104. Received March 24, 1986; revised July 14, 1986.

ASJC Scopus subject areas

  • Biological Psychiatry


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