Trichloroethylene and Parkinson Disease

Fariha Zaheer, John T. Slevin

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Multiple genetic and environmental etiologies have been implicated in the pathogenesis of idiopathic Parkinson disease. Recent observations have suggested an association between chronic exposure to trichloroethylene (TCE) and development of clinical parkinsonism. Animal models of TCE exposure have shown nigrostriatal degeneration and the development of parkinsonian features. Animal and cell culture models indicate mitochondrial dysfunction as the probable mechanism, most likely mediated by TaClo, a potential TCE metabolite. These observations endorse the hypothesis that a variety of environmental risk factors may cause nigrostriatal degeneration and clinical parkinsonism in genetically predisposed individuals.

Original languageEnglish
Pages (from-to)657-665
Number of pages9
JournalNeurologic Clinics
Volume29
Issue number3
DOIs
StatePublished - Aug 2011

Keywords

  • Alpha synuclein
  • Animal models
  • Idiopathic Parkinson disease
  • Mitochondria
  • Trichloroethylene

ASJC Scopus subject areas

  • Clinical Neurology

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