Trimethylsilylethynyl ketones as surrogates for ethynyl ketones in the double Michael reaction

Derrick S. Holeman; Ravindra M. Rasne; Robert B. Grossman

doi:10.1021/jo0163086

Trimethylsilylethynyl ketones as surrogates for ethynyl ketones in the double Michael reaction

Derrick S. Holeman, Ravindra M. Rasne, Robert B. Grossman

Chemistry

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Trimethylsilylethynyl ketones can be desilylated in the presence of a tethered carbon diacid and induced to undergo a double Michael reaction in situ. The trimethylsilylethynyl ketones can serve as surrogates of ethynyl ketones that are difficult to prepare or isolate.

Original language	English
Pages (from-to)	3149-3151
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	67
Issue number	9
DOIs	https://doi.org/10.1021/jo0163086
State	Published - May 3 2002

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo0163086

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title = "Trimethylsilylethynyl ketones as surrogates for ethynyl ketones in the double Michael reaction",

abstract = "Trimethylsilylethynyl ketones can be desilylated in the presence of a tethered carbon diacid and induced to undergo a double Michael reaction in situ. The trimethylsilylethynyl ketones can serve as surrogates of ethynyl ketones that are difficult to prepare or isolate.",

author = "Holeman, {Derrick S.} and Rasne, {Ravindra M.} and Grossman, {Robert B.}",

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doi = "10.1021/jo0163086",

language = "English",

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T1 - Trimethylsilylethynyl ketones as surrogates for ethynyl ketones in the double Michael reaction

AU - Holeman, Derrick S.

AU - Rasne, Ravindra M.

AU - Grossman, Robert B.

PY - 2002/5/3

Y1 - 2002/5/3

N2 - Trimethylsilylethynyl ketones can be desilylated in the presence of a tethered carbon diacid and induced to undergo a double Michael reaction in situ. The trimethylsilylethynyl ketones can serve as surrogates of ethynyl ketones that are difficult to prepare or isolate.

AB - Trimethylsilylethynyl ketones can be desilylated in the presence of a tethered carbon diacid and induced to undergo a double Michael reaction in situ. The trimethylsilylethynyl ketones can serve as surrogates of ethynyl ketones that are difficult to prepare or isolate.

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U2 - 10.1021/jo0163086

DO - 10.1021/jo0163086

M3 - Article

C2 - 11975585

AN - SCOPUS:0037012856

SN - 0022-3263

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 9

ER -

Trimethylsilylethynyl ketones as surrogates for ethynyl ketones in the double Michael reaction

Abstract

ASJC Scopus subject areas

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