TRP channels in airway sensory nerves

Qihai Gu, Lu Yuan Lee

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Transient Receptor Potential (TRP) channels expressed in specific subsets of airway sensory nerves function as transducers and integrators of a diverse range of sensory inputs including chemical, mechanical and thermal signals. These TRP sensors can detect inhaled irritants as well as endogenously released chemical substances. They play an important role in generating the afferent activity carried by these sensory nerves and regulating the centrally mediated pulmonary defense reflexes. Increasing evidence reported in recent investigations has revealed important involvements of several TRP channels (TRPA1, TRPV1, TRPV4 and TRPM8) in the manifestation of various symptoms and pathogenesis of certain acute and chronic airway diseases. This mini-review focuses primarily on these recent findings of the responses of these TRP sensors to the biological stresses emerging under the pathophysiological conditions of the lung and airways.

Original languageEnglish
Article number135719
JournalNeuroscience Letters
Volume748
DOIs
StatePublished - Mar 23 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier B.V.

Keywords

  • Airway
  • C-fiber
  • Lung
  • Respiratory disease
  • Transient receptor potential channel
  • Vagus

ASJC Scopus subject areas

  • General Neuroscience

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