Transient Receptor Potential (TRP) channels expressed in specific subsets of airway sensory nerves function as transducers and integrators of a diverse range of sensory inputs including chemical, mechanical and thermal signals. These TRP sensors can detect inhaled irritants as well as endogenously released chemical substances. They play an important role in generating the afferent activity carried by these sensory nerves and regulating the centrally mediated pulmonary defense reflexes. Increasing evidence reported in recent investigations has revealed important involvements of several TRP channels (TRPA1, TRPV1, TRPV4 and TRPM8) in the manifestation of various symptoms and pathogenesis of certain acute and chronic airway diseases. This mini-review focuses primarily on these recent findings of the responses of these TRP sensors to the biological stresses emerging under the pathophysiological conditions of the lung and airways.
|State||Published - Mar 23 2021|
Bibliographical noteFunding Information:
The publication was supported in part by U.S. National Institutes of Health grants AI123832 , UL1TR001998 and P30 ES026529-04S1 . Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the funding agencies.
© 2021 Elsevier B.V.
- Respiratory disease
- Transient receptor potential channel
ASJC Scopus subject areas
- Neuroscience (all)