TY - JOUR
T1 - Tumor necrosis factor-mediated hypoalbuminemia in rabbits
AU - Hennig, B.
AU - Honchel, R.
AU - Goldblum, S. E.
AU - McClain, C. J.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1988
Y1 - 1988
N2 - The serum albumin concentration is used clinically as an indicator of nutritional status and as a prognostic indicator. Critically ill patients, who display many aspects of the acute phase response, frequently have low serum albumin levels upon hospitalization. Cytokines, such as tumor necrosis factor (TNF), mediate many aspects of the acute phase response. One purpose of this study was to determine if TNF administration to healthy well-nourished rabbits could produce hypoalbuminemia. After intravenous administration of saline or TNF, the TNF-treated rabbits experienced significant hypoalbuminemia which was most prominent at 24 h and was partially corrected by 48 h. A second purpose was to evaluate the effects of TNF treatment on transendothelial movement of albumin using an in vitro porcine pulmonary artery - endothelial cell system. Exposure to TNF for 24 h resulted in a dose dependent increase in transendothelial passage of albumin. These data suggest that the mechanisms of hypoalbuminemia frequently observed in critically ill patients can be explained in part by cytokine (TNF)-induced endothelial cell injury, which results in enhanced endothelial permeability to albumin. The hypoalbuminemia observed in many critically ill patients thus may be unrelated to nutritional status, but rather may be related to the patient's underlying disease state.
AB - The serum albumin concentration is used clinically as an indicator of nutritional status and as a prognostic indicator. Critically ill patients, who display many aspects of the acute phase response, frequently have low serum albumin levels upon hospitalization. Cytokines, such as tumor necrosis factor (TNF), mediate many aspects of the acute phase response. One purpose of this study was to determine if TNF administration to healthy well-nourished rabbits could produce hypoalbuminemia. After intravenous administration of saline or TNF, the TNF-treated rabbits experienced significant hypoalbuminemia which was most prominent at 24 h and was partially corrected by 48 h. A second purpose was to evaluate the effects of TNF treatment on transendothelial movement of albumin using an in vitro porcine pulmonary artery - endothelial cell system. Exposure to TNF for 24 h resulted in a dose dependent increase in transendothelial passage of albumin. These data suggest that the mechanisms of hypoalbuminemia frequently observed in critically ill patients can be explained in part by cytokine (TNF)-induced endothelial cell injury, which results in enhanced endothelial permeability to albumin. The hypoalbuminemia observed in many critically ill patients thus may be unrelated to nutritional status, but rather may be related to the patient's underlying disease state.
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U2 - 10.1093/jn/118.12.1586
DO - 10.1093/jn/118.12.1586
M3 - Article
C2 - 3210085
AN - SCOPUS:0024271383
SN - 0022-3166
VL - 118
SP - 1586
EP - 1590
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 12
ER -