Tumor Necrosis Factor Receptors: A Brief Digestion

Y. Lin; B. P. Zhou

doi:10.1016/B978-0-12-394447-4.30006-2

Tumor Necrosis Factor Receptors: A Brief Digestion

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Members of the tumor necrosis factor receptor superfamily (TNFRSF) play essential roles in tissue development and homeostasis. Through unique receptor-ligand interaction, TNFRSF members become activated and recruit intracellular adaptor proteins to initiate diverse signaling pathways mediating cell survival, proliferation, differentiation, and apoptosis. Deregulation of TNFR pathways is associated with inflammatory and autoimmune disorders as well as cancer. Therapeutic strategies of targeting TNFRSF members and their ligands have been developed.

Original language	English
Title of host publication	Functional Cell Biology
Pages	61-66
Number of pages	6
Volume	3
ISBN (Electronic)	9780123944474
DOIs	https://doi.org/10.1016/B978-0-12-394447-4.30006-2
State	Published - 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.

Keywords

Cancer
Clinical targeting
Immunotherapy
Ligand-receptor interaction
Signal transduction
TNF
TNFR1
TNFR2
TNFRSF
TNFSF

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-394447-4.30006-2

Cite this

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AU - Zhou, B. P.

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AB - Members of the tumor necrosis factor receptor superfamily (TNFRSF) play essential roles in tissue development and homeostasis. Through unique receptor-ligand interaction, TNFRSF members become activated and recruit intracellular adaptor proteins to initiate diverse signaling pathways mediating cell survival, proliferation, differentiation, and apoptosis. Deregulation of TNFR pathways is associated with inflammatory and autoimmune disorders as well as cancer. Therapeutic strategies of targeting TNFRSF members and their ligands have been developed.

KW - Cancer

KW - Clinical targeting

KW - Immunotherapy

KW - Ligand-receptor interaction

KW - Signal transduction

KW - TNF

KW - TNFR1

KW - TNFR2

KW - TNFRSF

KW - TNFSF

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SN - 9780123947963

VL - 3

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EP - 66

BT - Functional Cell Biology

ER -

Tumor Necrosis Factor Receptors: A Brief Digestion

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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