Tumor Necrosis Factor Receptors: A Brief Digestion

Yiwei Lin; Zhibing Duan; Binhua P. Zhou

doi:10.1016/B978-0-12-821618-7.00162-0

Tumor Necrosis Factor Receptors: A Brief Digestion

Yiwei Lin, Zhibing Duan, Binhua P. Zhou

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Members of the tumor necrosis factor receptor superfamily (TNFRSF) play essential roles in tissue development and homeostasis. Through unique receptor–ligand interaction, TNFRSF members become activated and recruit intracellular adaptor proteins to initiate diverse signaling pathways mediating cell survival, proliferation, differentiation, and apoptosis. Deregulation of TNFR pathways is associated with inflammatory and autoimmune disorders as well as cancer. Therapeutic strategies of targeting TNFRSF members and their ligands have been developed.

Original language	English
Title of host publication	Encyclopedia of Cell Biology
Subtitle of host publication	Volume 1-6, Second Edition
Pages	78-84
Number of pages	7
Volume	4
ISBN (Electronic)	9780128216248
DOIs	https://doi.org/10.1016/B978-0-12-821618-7.00162-0
State	Published - Jan 1 2022

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Inc. All rights reserved.

Keywords

Cancer
Clinical targeting
Immunotherapy
Ligand–receptor interaction
Signal transduction
TNF
TNFR1
TNFR2
TNFRSF and TNFSF

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-821618-7.00162-0

Cite this

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KW - Cancer

KW - Clinical targeting

KW - Immunotherapy

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KW - Signal transduction

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KW - TNFR2

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M3 - Chapter

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BT - Encyclopedia of Cell Biology

ER -

Tumor Necrosis Factor Receptors: A Brief Digestion

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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