Abstract
Members of the tumor necrosis factor receptor superfamily (TNFRSF) play essential roles in tissue development and homeostasis. Through unique receptor-ligand interaction, TNFRSF members become activated and recruit intracellular adaptor proteins to initiate diverse signaling pathways mediating cell survival, proliferation, differentiation, and apoptosis. Deregulation of TNFR pathways is associated with inflammatory and autoimmune disorders as well as cancer. Therapeutic strategies of targeting TNFRSF members and their ligands have been developed.
| Original language | English |
|---|---|
| Title of host publication | Functional Cell Biology |
| Pages | 61-66 |
| Number of pages | 6 |
| Volume | 3 |
| ISBN (Electronic) | 9780123944474 |
| DOIs | |
| State | Published - 2016 |
Bibliographical note
Publisher Copyright:© 2016 Elsevier Inc. All rights reserved.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Cancer
- Clinical targeting
- Immunotherapy
- Ligand-receptor interaction
- Signal transduction
- TNF
- TNFR1
- TNFR2
- TNFRSF
- TNFSF
ASJC Scopus subject areas
- General Medicine
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