Many methods for sleep restriction in rodents have emerged, but most are intrusive, lack fine control, and induce stress. Therefore, a versatile, non-intrusive means of sleep restriction that can alter sleep in a controlled manner could be of great value in sleep research. In previous work, we proposed a novel system for closed-loop somatosensory stimulation based on mechanical vibration and applied it to the task of restricting Rapid Eye Movement (REM) sleep in mice . While this system was effective, it was a crude prototype and did not allow precise control over the amplitude and frequency of stimulation applied to the animal. This paper details the progression of this system from a binary, 'all-or-none' version to one that allows dynamic control over perturbation to accomplish graded, state-dependent sleep restriction. Its preliminary use is described in two applications: deep sleep restriction in rats, and REM sleep restriction in mice.
|Title of host publication||2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016|
|Number of pages||4|
|State||Published - Oct 13 2016|
|Event||38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 - Orlando, United States|
Duration: Aug 16 2016 → Aug 20 2016
|Name||Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS|
|Conference||38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016|
|Period||8/16/16 → 8/20/16|
Bibliographical notePublisher Copyright:
© 2016 IEEE.
ASJC Scopus subject areas
- Signal Processing
- Biomedical Engineering
- Computer Vision and Pattern Recognition
- Health Informatics