Abstract
Many methods for sleep restriction in rodents have emerged, but most are intrusive, lack fine control, and induce stress. Therefore, a versatile, non-intrusive means of sleep restriction that can alter sleep in a controlled manner could be of great value in sleep research. In previous work, we proposed a novel system for closed-loop somatosensory stimulation based on mechanical vibration and applied it to the task of restricting Rapid Eye Movement (REM) sleep in mice [1]. While this system was effective, it was a crude prototype and did not allow precise control over the amplitude and frequency of stimulation applied to the animal. This paper details the progression of this system from a binary, 'all-or-none' version to one that allows dynamic control over perturbation to accomplish graded, state-dependent sleep restriction. Its preliminary use is described in two applications: deep sleep restriction in rats, and REM sleep restriction in mice.
Original language | English |
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Title of host publication | 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 |
Pages | 1640-1643 |
Number of pages | 4 |
ISBN (Electronic) | 9781457702204 |
DOIs | |
State | Published - Oct 13 2016 |
Event | 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 - Orlando, United States Duration: Aug 16 2016 → Aug 20 2016 |
Publication series
Name | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
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Volume | 2016-October |
ISSN (Print) | 1557-170X |
Conference
Conference | 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 |
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Country/Territory | United States |
City | Orlando |
Period | 8/16/16 → 8/20/16 |
Bibliographical note
Publisher Copyright:© 2016 IEEE.
ASJC Scopus subject areas
- Signal Processing
- Biomedical Engineering
- Computer Vision and Pattern Recognition
- Health Informatics