Twenty Years of Studying AngII (Angiotensin II)-Induced Abdominal Aortic Pathologies in Mice: Continuing Questions and Challenges to Provide Insight into the Human Disease

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

AngII (angiotensin II) infusion in mice has been used to provide mechanistic insight into human abdominal aortic aneurysms for over 2 decades. This is a technically facile animal model that recapitulates multiple facets of the human disease. Although numerous publications have reported abdominal aortic aneurysms with AngII infusion in mice, there remain many fundamental unanswered questions such as uniformity of describing the pathological characteristics and which cell type is stimulated by AngII to promote abdominal aortic aneurysms. Extrapolation of the findings to provide insight into the human disease has been hindered by the preponderance of studies designed to determine the effects on initiation of abdominal aortic aneurysms, rather than a more clinically relevant scenario of determining efficacy on the established disease. The purpose of this review is to enhance understanding of AngII-induced abdominal aortic pathologies in mice, thereby providing greater insight into the human disease.

Original languageEnglish
Pages (from-to)277-288
Number of pages12
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume42
Issue number3
DOIs
StatePublished - Mar 1 2022

Bibliographical note

Funding Information:
The authors’ aortic aneurysm-related research work is supported by National Heart, Lung, and Blood Institute of the National Institutes of Health under award number R01HL133723, R35HL155649, and the American Heart Association SFRN in Vascular Disease (18SFRN33900001). The content in this commentary is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2021 Wolters Kluwer Health, Inc. All rights reserved.

Keywords

  • aneurysms
  • angiotensin
  • aorta
  • mechanism
  • mouse model

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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