Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice

Jennifer Alamed, Donna M. Wilcock, David M. Diamond, Marcia N. Gordon, Dave Morgan

Research output: Contribution to journalArticlepeer-review

190 Scopus citations

Abstract

The radial arm water maze (RAWM) contains six swim paths (arms) extending out of an open central area, with an escape platform located at the end of one arm (the goal arm). The goal arm location remains constant for a given mouse. On day 1, mice are trained for 15 trials (spaced over 3 h), with trials alternating between visible and hidden platform. On day 2, mice are trained for 15 trials with the hidden platform. Entry into an incorrect arm is scored as an error. The RAWM has the spatial complexity and performance measurement simplicity of the dry radial arm maze combined with the rapid learning and strong motivation observed in the Morris water maze without requiring foot shock or food deprivation as motivating factors. With two sessions each day, 16 mice can be tested over 2 days.

Original languageEnglish
Pages (from-to)1671-1679
Number of pages9
JournalNature Protocols
Volume1
Issue number4
DOIs
StatePublished - Nov 2006

Bibliographical note

Funding Information:
ACKNOWLEDGMENTS We have been supported by NIH awards AG15490, AG18478, AG25509, AG25711 and NS48335. D.W. was a Benjamin Scholar in Alzheimer’s Research.

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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