Two-headed PROTAC: An effective new tool for targeted protein degradation

Kedra Cyrus, Marie Wehenkel, Eun Young Choi, Hollie Swanson, Kyung Bo Kim

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Better than one: A novel class of PROTAC that recruits target protein for ubiquitination and subsequent degradation by the proteasome has been successfully synthesized and tested for its activity to degrade a target protein.

Original languageEnglish
Pages (from-to)1531-1534
Number of pages4
JournalChemBioChem
Volume11
Issue number11
DOIs
StatePublished - Jul 26 2010

Keywords

  • Estrogen receptor
  • Ligases
  • PROTAC
  • Proteomics
  • Ubiquitin-proteasome pathway

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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