Two-headed PROTAC: An effective new tool for targeted protein degradation

Kedra Cyrus, Marie Wehenkel, Eun Young Choi, Hollie Swanson, Kyung Bo Kim

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Better than one: A novel class of PROTAC that recruits target protein for ubiquitination and subsequent degradation by the proteasome has been successfully synthesized and tested for its activity to degrade a target protein.

Original languageEnglish
Pages (from-to)1531-1534
Number of pages4
JournalChemBioChem
Volume11
Issue number11
DOIs
StatePublished - Jul 26 2010

Funding

FundersFunder number
National Institutes of Health (NIH)R01CA131059
National Institute of Environmental Health Sciences (NIEHS)R01ES014849

    Keywords

    • Estrogen receptor
    • Ligases
    • PROTAC
    • Proteomics
    • Ubiquitin-proteasome pathway

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Organic Chemistry

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