Two-headed PROTAC: An effective new tool for targeted protein degradation

Kedra Cyrus; Marie Wehenkel; Eun Young Choi; Hollie Swanson; Kyung Bo Kim

doi:10.1002/cbic.201000222

Two-headed PROTAC: An effective new tool for targeted protein degradation

Kedra Cyrus, Marie Wehenkel, Eun Young Choi, Hollie Swanson, Kyung Bo Kim

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Better than one: A novel class of PROTAC that recruits target protein for ubiquitination and subsequent degradation by the proteasome has been successfully synthesized and tested for its activity to degrade a target protein.

Original language	English
Pages (from-to)	1531-1534
Number of pages	4
Journal	ChemBioChem
Volume	11
Issue number	11
DOIs	https://doi.org/10.1002/cbic.201000222
State	Published - Jul 26 2010

Keywords

Estrogen receptor
Ligases
PROTAC
Proteomics
Ubiquitin-proteasome pathway

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Organic Chemistry

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10.1002/cbic.201000222

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title = "Two-headed PROTAC: An effective new tool for targeted protein degradation",

abstract = "Better than one: A novel class of PROTAC that recruits target protein for ubiquitination and subsequent degradation by the proteasome has been successfully synthesized and tested for its activity to degrade a target protein.",

keywords = "Estrogen receptor, Ligases, PROTAC, Proteomics, Ubiquitin-proteasome pathway",

author = "Kedra Cyrus and Marie Wehenkel and Choi, {Eun Young} and Hollie Swanson and Kim, {Kyung Bo}",

year = "2010",

month = jul,

day = "26",

doi = "10.1002/cbic.201000222",

language = "English",

volume = "11",

pages = "1531--1534",

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T1 - Two-headed PROTAC

T2 - An effective new tool for targeted protein degradation

AU - Cyrus, Kedra

AU - Wehenkel, Marie

AU - Choi, Eun Young

AU - Swanson, Hollie

AU - Kim, Kyung Bo

PY - 2010/7/26

Y1 - 2010/7/26

N2 - Better than one: A novel class of PROTAC that recruits target protein for ubiquitination and subsequent degradation by the proteasome has been successfully synthesized and tested for its activity to degrade a target protein.

AB - Better than one: A novel class of PROTAC that recruits target protein for ubiquitination and subsequent degradation by the proteasome has been successfully synthesized and tested for its activity to degrade a target protein.

KW - Estrogen receptor

KW - Ligases

KW - PROTAC

KW - Proteomics

KW - Ubiquitin-proteasome pathway

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UR - http://www.scopus.com/inward/citedby.url?scp=77955162918&partnerID=8YFLogxK

U2 - 10.1002/cbic.201000222

DO - 10.1002/cbic.201000222

M3 - Article

C2 - 20572252

AN - SCOPUS:77955162918

VL - 11

SP - 1531

EP - 1534

IS - 11

ER -

Two-headed PROTAC: An effective new tool for targeted protein degradation

Abstract

Keywords

ASJC Scopus subject areas

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