Two lyophilized polymer matrix recombinant human bone morphogenetic protein-2 carriers in rabbit calvarial defects

Janet Becker Rodgers, Henry C. Vasconez, Mark D. Wells, Patrick P. DeLuca, Marie Claude Faugere, Betsy F. Fink, Doris Hamilton

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

We have developed a lyophilized bone morphogenetic protein (BMP) delivery device that can be formulated to control release over 2 to 8 weeks. Bioerodible poly (d,l lactide-co-glycolide) particles loaded with 90 μg recombinant human BMP-2 were suspended in either carboxymethylcellulose (CMC) or methylcellulose (MC) implants. Plain CMC and MC implants served as controls, as did a nonimplanted group. A total of 40 rabbits was evaluated histologically 2, 4, or 8 weeks after receiving circular full-thickness 15-mm calvarial defects. MC appeared to prevent prolapse of periosteum and dura into the defects and did not elicit bone growth. Addition of BMP improved the result. CMC implants appeared to encourage bone growth even in the absence of BMP. When BMP was added, new bone formed earlier. CMC may influence new bone formation because it is hydrophilic. MC is less hydrophilic and may cause undue inflammation. Either can be combined with BMP to produce unitary devices that are easy to make and use.

Original languageEnglish
Pages (from-to)147-153
Number of pages7
JournalJournal of Craniofacial Surgery
Volume9
Issue number2
DOIs
StatePublished - Mar 1998

Keywords

  • Biodegradable polymer
  • Bone morphogenetic protein
  • Calvarial bone
  • Drug delivery device
  • Rabbit

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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