Two-Photon In Vivo Imaging with Porous Silicon Nanoparticles

Dokyoung Kim; Jinyoung Kang; Taejun Wang; Hye Gun Ryu; Jonathan M. Zuidema; Jinmyoung Joo; Muwoong Kim; Youngbuhm Huh; Junyang Jung; Kyo Han Ahn; Ki Hean Kim; Michael J. Sailor

doi:10.1002/adma.201703309

Two-Photon In Vivo Imaging with Porous Silicon Nanoparticles

Dokyoung Kim, Jinyoung Kang, Taejun Wang, Hye Gun Ryu, Jonathan M. Zuidema, Jinmyoung Joo, Muwoong Kim, Youngbuhm Huh, Junyang Jung, Kyo Han Ahn, Ki Hean Kim, Michael J. Sailor

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

A major obstacle in luminescence imaging is the limited penetration of visible light into tissues and interference associated with light scattering and autofluorescence. Near-infrared (NIR) emitters that can also be excited with NIR radiation via two-photon processes can mitigate these factors somewhat because they operate at wavelengths of 650–1000 nm where tissues are more transparent, light scattering is less efficient, and endogenous fluorophores are less likely to absorb. This study presents photolytically stable, NIR photoluminescent, porous silicon nanoparticles with a relatively high two-photon-absorption cross-section and a large emission quantum yield. Their ability to be targeted to tumor tissues in vivo using the iRGD targeting peptide is demonstrated, and the distribution of the nanoparticles with high spatial resolution is visualized.

Original language	English
Article number	1703309
Journal	Advanced Materials
Volume	29
Issue number	39
DOIs	https://doi.org/10.1002/adma.201703309
State	Published - Oct 18 2017

Bibliographical note

Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

cancer diagnostics
iRGD targeting peptide
nanomedicine
photoluminescence

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/adma.201703309

Cite this

@article{2b9339167ea64045a84f50cf1c72c527,

title = "Two-Photon In Vivo Imaging with Porous Silicon Nanoparticles",

abstract = "A major obstacle in luminescence imaging is the limited penetration of visible light into tissues and interference associated with light scattering and autofluorescence. Near-infrared (NIR) emitters that can also be excited with NIR radiation via two-photon processes can mitigate these factors somewhat because they operate at wavelengths of 650–1000 nm where tissues are more transparent, light scattering is less efficient, and endogenous fluorophores are less likely to absorb. This study presents photolytically stable, NIR photoluminescent, porous silicon nanoparticles with a relatively high two-photon-absorption cross-section and a large emission quantum yield. Their ability to be targeted to tumor tissues in vivo using the iRGD targeting peptide is demonstrated, and the distribution of the nanoparticles with high spatial resolution is visualized.",

keywords = "cancer diagnostics, iRGD targeting peptide, nanomedicine, photoluminescence",

author = "Dokyoung Kim and Jinyoung Kang and Taejun Wang and Ryu, {Hye Gun} and Zuidema, {Jonathan M.} and Jinmyoung Joo and Muwoong Kim and Youngbuhm Huh and Junyang Jung and Ahn, {Kyo Han} and Kim, {Ki Hean} and Sailor, {Michael J.}",

note = "Publisher Copyright: {\textcopyright} 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2017",

month = oct,

day = "18",

doi = "10.1002/adma.201703309",

language = "English",

volume = "29",

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T1 - Two-Photon In Vivo Imaging with Porous Silicon Nanoparticles

AU - Kim, Dokyoung

AU - Kang, Jinyoung

AU - Wang, Taejun

AU - Ryu, Hye Gun

AU - Zuidema, Jonathan M.

AU - Joo, Jinmyoung

AU - Kim, Muwoong

AU - Huh, Youngbuhm

AU - Jung, Junyang

AU - Ahn, Kyo Han

AU - Kim, Ki Hean

AU - Sailor, Michael J.

PY - 2017/10/18

Y1 - 2017/10/18

N2 - A major obstacle in luminescence imaging is the limited penetration of visible light into tissues and interference associated with light scattering and autofluorescence. Near-infrared (NIR) emitters that can also be excited with NIR radiation via two-photon processes can mitigate these factors somewhat because they operate at wavelengths of 650–1000 nm where tissues are more transparent, light scattering is less efficient, and endogenous fluorophores are less likely to absorb. This study presents photolytically stable, NIR photoluminescent, porous silicon nanoparticles with a relatively high two-photon-absorption cross-section and a large emission quantum yield. Their ability to be targeted to tumor tissues in vivo using the iRGD targeting peptide is demonstrated, and the distribution of the nanoparticles with high spatial resolution is visualized.

AB - A major obstacle in luminescence imaging is the limited penetration of visible light into tissues and interference associated with light scattering and autofluorescence. Near-infrared (NIR) emitters that can also be excited with NIR radiation via two-photon processes can mitigate these factors somewhat because they operate at wavelengths of 650–1000 nm where tissues are more transparent, light scattering is less efficient, and endogenous fluorophores are less likely to absorb. This study presents photolytically stable, NIR photoluminescent, porous silicon nanoparticles with a relatively high two-photon-absorption cross-section and a large emission quantum yield. Their ability to be targeted to tumor tissues in vivo using the iRGD targeting peptide is demonstrated, and the distribution of the nanoparticles with high spatial resolution is visualized.

KW - cancer diagnostics

KW - iRGD targeting peptide

KW - nanomedicine

KW - photoluminescence

UR - http://www.scopus.com/inward/record.url?scp=85027720082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027720082&partnerID=8YFLogxK

U2 - 10.1002/adma.201703309

DO - 10.1002/adma.201703309

M3 - Article

C2 - 28833739

AN - SCOPUS:85027720082

SN - 0935-9648

VL - 29

JO - Advanced Materials

JF - Advanced Materials

IS - 39

M1 - 1703309

ER -

Two-Photon In Vivo Imaging with Porous Silicon Nanoparticles

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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