TY - JOUR
T1 - Type 2 Diabetes Mellitus and Heart Failure, A Scientific Statement From the American Heart Association and Heart Failure Society of America
AU - Dunlay, Shannon M.
AU - Givertz, Michael M.
AU - Aguilar, D.
AU - Allen, Larry A.
AU - Chan, Michael
AU - Desai, Akshay S.
AU - Deswal, A.
AU - Dickson, Victoria Vaughan
AU - Kosiborod, Mikhail N.
AU - Lekavich, Carolyn L.
AU - McCoy, Rozalina G.
AU - Mentz, Robert J.
AU - PiÑa, Ileana L.
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/8
Y1 - 2019/8
N2 - Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of morbidity and mortality in patients with established disease. Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden of disease and underscore the need for effective therapeutic strategies. Recent clinical trials have demonstrated the shared pathophysiology between diabetes mellitus and heart failure, the synergistic effect of managing both conditions, and the potential for diabetes mellitus therapies to modulate the risk of heart failure outcomes. This scientific statement on diabetes mellitus and heart failure summarizes the epidemiology, pathophysiology, and impact of diabetes mellitus and its control on outcomes in heart failure; reviews the approach to pharmacological therapy and lifestyle modification in patients with diabetes mellitus and heart failure; highlights the value of multidisciplinary interventions to improve clinical outcomes in this population; and outlines priorities for future research.
AB - Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of morbidity and mortality in patients with established disease. Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden of disease and underscore the need for effective therapeutic strategies. Recent clinical trials have demonstrated the shared pathophysiology between diabetes mellitus and heart failure, the synergistic effect of managing both conditions, and the potential for diabetes mellitus therapies to modulate the risk of heart failure outcomes. This scientific statement on diabetes mellitus and heart failure summarizes the epidemiology, pathophysiology, and impact of diabetes mellitus and its control on outcomes in heart failure; reviews the approach to pharmacological therapy and lifestyle modification in patients with diabetes mellitus and heart failure; highlights the value of multidisciplinary interventions to improve clinical outcomes in this population; and outlines priorities for future research.
KW - AHA Scientific Statement
KW - Diabetes mellitus, type 2
KW - Drug therapy
KW - Heart failure
KW - Lifestyle
KW - Risk factors
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U2 - 10.1016/j.cardfail.2019.05.007
DO - 10.1016/j.cardfail.2019.05.007
M3 - Article
C2 - 31167558
AN - SCOPUS:85070222492
SN - 1071-9164
VL - 25
SP - 584
EP - 619
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
IS - 8
ER -
