Type 2 diabetes mellitus and heart failure a scientific statement from the American Heart Association and the Heart Failure Society of America

Shannon M. Dunlay; Michael M. Givertz; David Aguilar; Larry A. Allen; Michael Chan; Akshay S. Desai; Anita Deswal; Victoria Vaughan Dickson; Mikhail N. Kosiborod; Carolyn L. Lekavich; Rozalina G. McCoy; Robert J. Mentz; Ileana L. Piña

doi:10.1161/CIR.0000000000000691

Type 2 diabetes mellitus and heart failure a scientific statement from the American Heart Association and the Heart Failure Society of America

Shannon M. Dunlay, Michael M. Givertz, David Aguilar, Larry A. Allen, Michael Chan, Akshay S. Desai, Anita Deswal, Victoria Vaughan Dickson, Mikhail N. Kosiborod, Carolyn L. Lekavich, Rozalina G. McCoy, Robert J. Mentz, Ileana L. Piña

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

421 Citations (SciVal)

Abstract

Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of morbidity and mortality in patients with established disease. Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden of disease and underscore the need for effective therapeutic strategies. Recent clinical trials have demonstrated the shared pathophysiology between diabetes mellitus and heart failure, the synergistic effect of managing both conditions, and the potential for diabetes mellitus therapies to modulate the risk of heart failure outcomes. This scientific statement on diabetes mellitus and heart failure summarizes the epidemiology, pathophysiology, and impact of diabetes mellitus and its control on outcomes in heart failure; reviews the approach to pharmacological therapy and lifestyle modification in patients with diabetes mellitus and heart failure; highlights the value of multidisciplinary interventions to improve clinical outcomes in this population; and outlines priorities for future research.

Original language	English
Pages (from-to)	E294-E324
Journal	Circulation
Volume	140
Issue number	7
DOIs	https://doi.org/10.1161/CIR.0000000000000691
State	Published - Aug 13 2019

Bibliographical note

Publisher Copyright:
© 2019 American Heart Association, Inc.

Keywords

AHA Scientific Statement
Diabetes mellitus, type 2
Drug therapy
Heart failure
Lifestyle
Risk factors

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/CIR.0000000000000691

Cite this

Dunlay, S. M., Givertz, M. M., Aguilar, D., Allen, L. A., Chan, M., Desai, A. S., Deswal, A., Dickson, V. V., Kosiborod, M. N., Lekavich, C. L., McCoy, R. G., Mentz, R. J., & Piña, I. L. (2019). Type 2 diabetes mellitus and heart failure a scientific statement from the American Heart Association and the Heart Failure Society of America. Circulation, 140(7), E294-E324. https://doi.org/10.1161/CIR.0000000000000691

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abstract = "Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of morbidity and mortality in patients with established disease. Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden of disease and underscore the need for effective therapeutic strategies. Recent clinical trials have demonstrated the shared pathophysiology between diabetes mellitus and heart failure, the synergistic effect of managing both conditions, and the potential for diabetes mellitus therapies to modulate the risk of heart failure outcomes. This scientific statement on diabetes mellitus and heart failure summarizes the epidemiology, pathophysiology, and impact of diabetes mellitus and its control on outcomes in heart failure; reviews the approach to pharmacological therapy and lifestyle modification in patients with diabetes mellitus and heart failure; highlights the value of multidisciplinary interventions to improve clinical outcomes in this population; and outlines priorities for future research.",

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Dunlay, SM, Givertz, MM, Aguilar, D, Allen, LA, Chan, M, Desai, AS, Deswal, A, Dickson, VV, Kosiborod, MN, Lekavich, CL, McCoy, RG, Mentz, RJ & Piña, IL 2019, 'Type 2 diabetes mellitus and heart failure a scientific statement from the American Heart Association and the Heart Failure Society of America', Circulation, vol. 140, no. 7, pp. E294-E324. https://doi.org/10.1161/CIR.0000000000000691

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AU - Desai, Akshay S.

AU - Deswal, Anita

AU - Dickson, Victoria Vaughan

AU - Kosiborod, Mikhail N.

AU - Lekavich, Carolyn L.

AU - McCoy, Rozalina G.

AU - Mentz, Robert J.

AU - Piña, Ileana L.

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AB - Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of morbidity and mortality in patients with established disease. Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden of disease and underscore the need for effective therapeutic strategies. Recent clinical trials have demonstrated the shared pathophysiology between diabetes mellitus and heart failure, the synergistic effect of managing both conditions, and the potential for diabetes mellitus therapies to modulate the risk of heart failure outcomes. This scientific statement on diabetes mellitus and heart failure summarizes the epidemiology, pathophysiology, and impact of diabetes mellitus and its control on outcomes in heart failure; reviews the approach to pharmacological therapy and lifestyle modification in patients with diabetes mellitus and heart failure; highlights the value of multidisciplinary interventions to improve clinical outcomes in this population; and outlines priorities for future research.

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KW - Diabetes mellitus, type 2

KW - Drug therapy

KW - Heart failure

KW - Lifestyle

KW - Risk factors

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Type 2 diabetes mellitus and heart failure a scientific statement from the American Heart Association and the Heart Failure Society of America

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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