Type 2 diabetes mellitus and heart failure a scientific statement from the American Heart Association and the Heart Failure Society of America

Shannon M. Dunlay; Michael M. Givertz; David Aguilar; Larry A. Allen; Michael Chan; Akshay S. Desai; Anita Deswal; Victoria Vaughan Dickson; Mikhail N. Kosiborod; Carolyn L. Lekavich; Rozalina G. McCoy; Robert J. Mentz; Ileana L. Piña

doi:10.1161/CIR.0000000000000691

Type 2 diabetes mellitus and heart failure a scientific statement from the American Heart Association and the Heart Failure Society of America

Shannon M. Dunlay
, Michael M. Givertz
, David Aguilar
, Larry A. Allen
, Michael Chan
, Akshay S. Desai
, Anita Deswal
, Victoria Vaughan Dickson
, Mikhail N. Kosiborod
, Carolyn L. Lekavich
, Rozalina G. McCoy
, Robert J. Mentz
, Ileana L. Piña

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

538 Scopus citations

Abstract

Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of morbidity and mortality in patients with established disease. Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden of disease and underscore the need for effective therapeutic strategies. Recent clinical trials have demonstrated the shared pathophysiology between diabetes mellitus and heart failure, the synergistic effect of managing both conditions, and the potential for diabetes mellitus therapies to modulate the risk of heart failure outcomes. This scientific statement on diabetes mellitus and heart failure summarizes the epidemiology, pathophysiology, and impact of diabetes mellitus and its control on outcomes in heart failure; reviews the approach to pharmacological therapy and lifestyle modification in patients with diabetes mellitus and heart failure; highlights the value of multidisciplinary interventions to improve clinical outcomes in this population; and outlines priorities for future research.

Original language	English
Pages (from-to)	E294-E324
Journal	Circulation
Volume	140
Issue number	7
DOIs	https://doi.org/10.1161/CIR.0000000000000691
State	Published - Aug 13 2019

Bibliographical note

Publisher Copyright:
© 2019 American Heart Association, Inc.

Funding

Novartis (research grant to Brigham and Women’s Hospital)†

Funders
AstraZeneca
Boehringer-Ingelheim

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

AHA Scientific Statement
Diabetes mellitus, type 2
Drug therapy
Heart failure
Lifestyle
Risk factors

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

Access to Document

10.1161/CIR.0000000000000691

Cite this

Dunlay, S. M., Givertz, M. M., Aguilar, D., Allen, L. A., Chan, M., Desai, A. S., Deswal, A., Dickson, V. V., Kosiborod, M. N., Lekavich, C. L., McCoy, R. G., Mentz, R. J., & Piña, I. L. (2019). Type 2 diabetes mellitus and heart failure a scientific statement from the American Heart Association and the Heart Failure Society of America. Circulation, 140(7), E294-E324. https://doi.org/10.1161/CIR.0000000000000691

@article{e2e91072675a41a1bc14beea674f7382,

title = "Type 2 diabetes mellitus and heart failure a scientific statement from the American Heart Association and the Heart Failure Society of America",

abstract = "Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of morbidity and mortality in patients with established disease. Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden of disease and underscore the need for effective therapeutic strategies. Recent clinical trials have demonstrated the shared pathophysiology between diabetes mellitus and heart failure, the synergistic effect of managing both conditions, and the potential for diabetes mellitus therapies to modulate the risk of heart failure outcomes. This scientific statement on diabetes mellitus and heart failure summarizes the epidemiology, pathophysiology, and impact of diabetes mellitus and its control on outcomes in heart failure; reviews the approach to pharmacological therapy and lifestyle modification in patients with diabetes mellitus and heart failure; highlights the value of multidisciplinary interventions to improve clinical outcomes in this population; and outlines priorities for future research.",

keywords = "AHA Scientific Statement, Diabetes mellitus, type 2, Drug therapy, Heart failure, Lifestyle, Risk factors",

author = "Dunlay, \{Shannon M.\} and Givertz, \{Michael M.\} and David Aguilar and Allen, \{Larry A.\} and Michael Chan and Desai, \{Akshay S.\} and Anita Deswal and Dickson, \{Victoria Vaughan\} and Kosiborod, \{Mikhail N.\} and Lekavich, \{Carolyn L.\} and McCoy, \{Rozalina G.\} and Mentz, \{Robert J.\} and Pi{\~n}a, \{Ileana L.\}",

note = "Publisher Copyright: {\textcopyright} 2019 American Heart Association, Inc.",

year = "2019",

month = aug,

day = "13",

doi = "10.1161/CIR.0000000000000691",

language = "English",

volume = "140",

pages = "E294--E324",

number = "7",

}

Dunlay, SM, Givertz, MM, Aguilar, D, Allen, LA, Chan, M, Desai, AS, Deswal, A, Dickson, VV, Kosiborod, MN, Lekavich, CL, McCoy, RG, Mentz, RJ & Piña, IL 2019, 'Type 2 diabetes mellitus and heart failure a scientific statement from the American Heart Association and the Heart Failure Society of America', Circulation, vol. 140, no. 7, pp. E294-E324. https://doi.org/10.1161/CIR.0000000000000691

TY - JOUR

T1 - Type 2 diabetes mellitus and heart failure a scientific statement from the American Heart Association and the Heart Failure Society of America

AU - Dunlay, Shannon M.

AU - Givertz, Michael M.

AU - Aguilar, David

AU - Allen, Larry A.

AU - Chan, Michael

AU - Desai, Akshay S.

AU - Deswal, Anita

AU - Dickson, Victoria Vaughan

AU - Kosiborod, Mikhail N.

AU - Lekavich, Carolyn L.

AU - McCoy, Rozalina G.

AU - Mentz, Robert J.

AU - Piña, Ileana L.

PY - 2019/8/13

Y1 - 2019/8/13

N2 - Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of morbidity and mortality in patients with established disease. Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden of disease and underscore the need for effective therapeutic strategies. Recent clinical trials have demonstrated the shared pathophysiology between diabetes mellitus and heart failure, the synergistic effect of managing both conditions, and the potential for diabetes mellitus therapies to modulate the risk of heart failure outcomes. This scientific statement on diabetes mellitus and heart failure summarizes the epidemiology, pathophysiology, and impact of diabetes mellitus and its control on outcomes in heart failure; reviews the approach to pharmacological therapy and lifestyle modification in patients with diabetes mellitus and heart failure; highlights the value of multidisciplinary interventions to improve clinical outcomes in this population; and outlines priorities for future research.

AB - Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of morbidity and mortality in patients with established disease. Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden of disease and underscore the need for effective therapeutic strategies. Recent clinical trials have demonstrated the shared pathophysiology between diabetes mellitus and heart failure, the synergistic effect of managing both conditions, and the potential for diabetes mellitus therapies to modulate the risk of heart failure outcomes. This scientific statement on diabetes mellitus and heart failure summarizes the epidemiology, pathophysiology, and impact of diabetes mellitus and its control on outcomes in heart failure; reviews the approach to pharmacological therapy and lifestyle modification in patients with diabetes mellitus and heart failure; highlights the value of multidisciplinary interventions to improve clinical outcomes in this population; and outlines priorities for future research.

KW - AHA Scientific Statement

KW - Diabetes mellitus, type 2

KW - Drug therapy

KW - Heart failure

KW - Lifestyle

KW - Risk factors

UR - https://www.scopus.com/pages/publications/85069624339

UR - https://www.scopus.com/pages/publications/85069624339#tab=citedBy

U2 - 10.1161/CIR.0000000000000691

DO - 10.1161/CIR.0000000000000691

M3 - Review article

C2 - 31167558

AN - SCOPUS:85069624339

SN - 0009-7322

VL - 140

SP - E294-E324

JO - Circulation

JF - Circulation

IS - 7

ER -

Type 2 diabetes mellitus and heart failure a scientific statement from the American Heart Association and the Heart Failure Society of America

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this