Type 3 ILCs in lung disease

Amanda Ardain, James Zachary Porterfield, Henrik N. Kløverpris, Alasdair Leslie

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from infection, mediate tissue repair, and maintain lung function. Innate lymphoid cells (ILCs) play a central role in tissue repair and homeostasis, and mediate protective immunity in a variety of mucosal tissues, including the lung. All three ILC subsets are present in the airways of both mice and humans; and ILC2s shown to have pivotal roles in asthma, airway hyper-responsiveness, and parasitic worm infection. The involvement of ILC3s in respiratory diseases is less well-defined, but they are known to be critical in homeostasis, infection and inflammation at other mucosal barriers, such as the gut. Moreover, they are important players in the IL17/IL22 axis, which is key to lung health. In this review, we discuss the emerging role of ILC3s in the context of infectious and inflammatory lung diseases, with a focus on data from human subjects.

Original languageEnglish
Article number92
JournalFrontiers in Immunology
Volume10
Issue numberJAN
DOIs
StatePublished - 2019

Bibliographical note

Funding Information:
This work was supported by Wellcome Trust by AL Grant No. 210662/Z/18/Z; HK Grant No. 202485/Z/16/Z.

Publisher Copyright:
© 2019 Ardain, Porterfield, Kløverpris and Leslie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Keywords

  • Airway hypersensitivity
  • COPD
  • ILC3
  • Lung disease
  • Pnemonia
  • Pulmonary fibrosis
  • Tuberulosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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