Tyrosine phosphorylation in Toll-like receptor signaling

Saurabh Chattopadhyay, Ganes C. Sen

Research output: Contribution to journalShort surveypeer-review

77 Scopus citations

Abstract

There is a wealth of knowledge about how different Ser/Thr protein kinases participate in Toll-like receptor (TLR) signaling. In many cases, we know the identities of the Ser/Thr residues of various components of the TLR-signaling pathways that are phosphorylated, the functional consequences of the phosphorylation and the responsible protein kinases. In contrast, the analysis of Tyr-phosphorylation of TLRs and their signaling proteins is currently incomplete, because several existing analyses are not systematic or they do not rely on robust experimental data. Nevertheless, it is clear that many TLRs require, for signaling, ligand-dependent phosphorylation of specific Tyr residues in their cytoplasmic domains; the list includes TLR2, TLR3, TLR4, TLR5, TLR8 and TLR9. In this article, we discuss the current status of knowledge of the effect of Tyr-phosphorylation of TLRs and their signaling proteins on their biochemical and biological functions, the possible identities of the relevant protein tyrosine kinases (PTKs) and the nature of regulations of PTK-mediated activation of TLR signaling pathways.

Original languageEnglish
Pages (from-to)533-541
Number of pages9
JournalCytokine and Growth Factor Reviews
Volume25
Issue number5
DOIs
StatePublished - Oct 1 2014

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Ltd.

Keywords

  • EGFR
  • Protein tyrosine kinases
  • Src
  • TLR
  • Tyrosine phosphorylation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • General Biochemistry, Genetics and Molecular Biology

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