Ubiquitin regulation: The histone modifying enzyme’s story

Jianlin Wang, Zhaoping Qiu, Yadi Wu

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Histone post-translational modifications influence many fundamental cellular events by regulating chromatin structure and gene transcriptional activity. These modifications are highly dynamic and tightly controlled, with many enzymes devoted to the addition and removal of these modifications. Interestingly, these modifying enzymes are themselves fine-tuned and precisely regulated at the level of protein turnover by ubiquitin-proteasomal processing. Here, we focus on recent progress centered on the mechanisms regulating ubiquitination of histone modifying enzymes, including ubiquitin proteasomal degradation and the reverse process of deubiquitination. We will also discuss the potential pathophysiological significance of these processes.

Original languageEnglish
Article number118
JournalCells
Volume7
Issue number9
DOIs
StatePublished - Sep 2018

Bibliographical note

Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Epigenetic
  • Histone modifying enzyme
  • Protein degradation
  • Ubiquitin

ASJC Scopus subject areas

  • General Medicine

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