Ultrasound modulated bioluminescence tomography with a single optical measurement

Francis Chung, Tianyu Yang, Yang Yang

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Ultrasound modulated bioluminescence tomography is an imaging method which can be formulated as a hybrid inverse source problem. In the regime where light propagation is modeled by a radiative transfer equation, previous approaches to this problem require large numbers of optical measurements (Bal et al 2016 SIAM J. Math. Anal. 48 1332). Here we propose an alternative solution for this inverse problem which requires only a single optical measurement in order to reconstruct the isotropic source. Specifically, we derive two inversion formulae based on Neumann series and Fredholm theory respectively, and prove their convergence under sufficient conditions. The resulting numerical algorithms are implemented and experimented to reconstruct both continuous and discontinuous sources in the presence of noise.

Original languageEnglish
Article number015004
JournalInverse Problems
Issue number1
StatePublished - Jan 1 2021

Bibliographical note

Publisher Copyright:
© 2020 IOP Publishing Ltd Printed in the UK


  • Bioluminescence tomography
  • Hybrid imaging
  • Internal data
  • Inverse source problem
  • Optical tomography
  • Radiative transfer equation
  • Ultrasound modulation

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Signal Processing
  • Mathematical Physics
  • Computer Science Applications
  • Applied Mathematics


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