Ultrastructural localization of amyloid P component in primary localized cutaneous amyloidosis

S. M. BREATHNACH, S. M. MELROSE, B. BHOGAL, F. C. DeBEER, M. M. BLACK, M. B. PEPYS

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Amyloid P component (AP) was specifically localized to dermal amyloid deposits in the papular and nodular variants of primary localized cutaneous amyloidosis by an immunoperoxidase technique using an antibody to serum amyloid P component (SAP). Specific staining with anti‐SAP of elastic fibre microfibrils which has previously been observed in normal skin, was also present and was noted in close proximity 10 deposits of amyloid material. AP associated with normal elastic fibre microfibrils may be involved in the deposition of amyloid fibrils in vivo.

Original languageEnglish
Pages (from-to)355-362
Number of pages8
JournalClinical and Experimental Dermatology
Volume8
Issue number4
DOIs
StatePublished - Jul 1983

ASJC Scopus subject areas

  • Dermatology

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