Understanding associations between serious mental illness and hepatitis C virus among veterans: A national multivariate analysis

Seth Himelhoch; John F. McCarthy; Dara Ganoczy; Deborah Medoff; Amy Kilbourne; Richard Goldberg; Lisa Dixon; Frederic C. Blow

doi:10.1176/appi.psy.50.1.30

Understanding associations between serious mental illness and hepatitis C virus among veterans: A national multivariate analysis

Seth Himelhoch, John F. McCarthy, Dara Ganoczy, Deborah Medoff, Amy Kilbourne, Richard Goldberg, Lisa Dixon, Frederic C. Blow

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Background: Hepatitis C virus (HCV) is a leading cause of hepatocellular carcinoma and cirrhosis in the United States and is known to be transmitted via pathways associated with substance use (e.g., injection drug use and intranasal drug use). Objective: Although individuals with serious mental illness (SMI) have a high prevalence of HCV, the nature of this relationship is unclear and is the subject of this investigation. Method: The authors determined unadjusted and adjusted recorded prevalence of HCV among a national sample of veterans with and without SMI. Results: HCV was recorded in 8.1% of patients with bipolar disorder, 7.1% of patients with schizophrenia, and 2.5% of patients without SMI. Substance use increased HCV risk among SMI patients; patients with bipolar disorder had greater risk than patients with schizophrenia. Conclusion: Efforts to address HCV among patients with serious mental illness and co-occurring substance abuse are warranted.

Original language	English
Pages (from-to)	30-37
Number of pages	8
Journal	Psychosomatics
Volume	50
Issue number	1
DOIs	https://doi.org/10.1176/appi.psy.50.1.30
State	Published - 2009

Bibliographical note

Funding Information:
This work was funded by VA Capitol Health Care Network MIRECC , NIDA K-23 DA019820 , to Dr. Himelhoch; a VA Health Services Research and Development Career Development Award Merit Review Entry ProgramMRP 03–320, to Dr. McCarthy; and Grant MRP 02–269 and IIR 02–283, to Dr. Kilbourne.

Funding

This work was funded by VA Capitol Health Care Network MIRECC , NIDA K-23 DA019820 , to Dr. Himelhoch; a VA Health Services Research and Development Career Development Award Merit Review Entry ProgramMRP 03–320, to Dr. McCarthy; and Grant MRP 02–269 and IIR 02–283, to Dr. Kilbourne.

Funders

Funder number

VA Capitol Health Care Network MIRECC

Author National Institute on Drug Abuse DA031791 Mark J Ferris National Institute on Drug Abuse DA006634 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA026117 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA028162 Elizabeth G Pitts National Institute of General Medical Sciences GM102773 Elizabeth G Pitts Peter McManus Charitable Trust Mark J Ferris National Institute on Drug Abuse

IIR 02–283, K23DA019820, MRP 02–269

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Applied Psychology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1176/appi.psy.50.1.30

Cite this

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title = "Understanding associations between serious mental illness and hepatitis C virus among veterans: A national multivariate analysis",

abstract = "Background: Hepatitis C virus (HCV) is a leading cause of hepatocellular carcinoma and cirrhosis in the United States and is known to be transmitted via pathways associated with substance use (e.g., injection drug use and intranasal drug use). Objective: Although individuals with serious mental illness (SMI) have a high prevalence of HCV, the nature of this relationship is unclear and is the subject of this investigation. Method: The authors determined unadjusted and adjusted recorded prevalence of HCV among a national sample of veterans with and without SMI. Results: HCV was recorded in 8.1\% of patients with bipolar disorder, 7.1\% of patients with schizophrenia, and 2.5\% of patients without SMI. Substance use increased HCV risk among SMI patients; patients with bipolar disorder had greater risk than patients with schizophrenia. Conclusion: Efforts to address HCV among patients with serious mental illness and co-occurring substance abuse are warranted.",

author = "Seth Himelhoch and McCarthy, \{John F.\} and Dara Ganoczy and Deborah Medoff and Amy Kilbourne and Richard Goldberg and Lisa Dixon and Blow, \{Frederic C.\}",

note = "Funding Information: This work was funded by VA Capitol Health Care Network MIRECC , NIDA K-23 DA019820 , to Dr. Himelhoch; a VA Health Services Research and Development Career Development Award Merit Review Entry ProgramMRP 03–320, to Dr. McCarthy; and Grant MRP 02–269 and IIR 02–283, to Dr. Kilbourne.",

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doi = "10.1176/appi.psy.50.1.30",

language = "English",

volume = "50",

pages = "30--37",

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T1 - Understanding associations between serious mental illness and hepatitis C virus among veterans

T2 - A national multivariate analysis

AU - Himelhoch, Seth

AU - McCarthy, John F.

AU - Ganoczy, Dara

AU - Medoff, Deborah

AU - Kilbourne, Amy

AU - Goldberg, Richard

AU - Dixon, Lisa

AU - Blow, Frederic C.

N1 - Funding Information: This work was funded by VA Capitol Health Care Network MIRECC , NIDA K-23 DA019820 , to Dr. Himelhoch; a VA Health Services Research and Development Career Development Award Merit Review Entry ProgramMRP 03–320, to Dr. McCarthy; and Grant MRP 02–269 and IIR 02–283, to Dr. Kilbourne.

PY - 2009

Y1 - 2009

N2 - Background: Hepatitis C virus (HCV) is a leading cause of hepatocellular carcinoma and cirrhosis in the United States and is known to be transmitted via pathways associated with substance use (e.g., injection drug use and intranasal drug use). Objective: Although individuals with serious mental illness (SMI) have a high prevalence of HCV, the nature of this relationship is unclear and is the subject of this investigation. Method: The authors determined unadjusted and adjusted recorded prevalence of HCV among a national sample of veterans with and without SMI. Results: HCV was recorded in 8.1% of patients with bipolar disorder, 7.1% of patients with schizophrenia, and 2.5% of patients without SMI. Substance use increased HCV risk among SMI patients; patients with bipolar disorder had greater risk than patients with schizophrenia. Conclusion: Efforts to address HCV among patients with serious mental illness and co-occurring substance abuse are warranted.

AB - Background: Hepatitis C virus (HCV) is a leading cause of hepatocellular carcinoma and cirrhosis in the United States and is known to be transmitted via pathways associated with substance use (e.g., injection drug use and intranasal drug use). Objective: Although individuals with serious mental illness (SMI) have a high prevalence of HCV, the nature of this relationship is unclear and is the subject of this investigation. Method: The authors determined unadjusted and adjusted recorded prevalence of HCV among a national sample of veterans with and without SMI. Results: HCV was recorded in 8.1% of patients with bipolar disorder, 7.1% of patients with schizophrenia, and 2.5% of patients without SMI. Substance use increased HCV risk among SMI patients; patients with bipolar disorder had greater risk than patients with schizophrenia. Conclusion: Efforts to address HCV among patients with serious mental illness and co-occurring substance abuse are warranted.

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Understanding associations between serious mental illness and hepatitis C virus among veterans: A national multivariate analysis

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

UN SDGs

Access to Document

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