Unexpected doxorubicin-mediated cardiotoxicity in sisters: Possible role of polymorphisms in histamine n-methyl transferase

Kamakshi Sachidanandam; Arlene A. Gayle; H. Ian Robins; Jill M. Kolesar

doi:10.1177/1078155212461022

Unexpected doxorubicin-mediated cardiotoxicity in sisters: Possible role of polymorphisms in histamine n-methyl transferase

Kamakshi Sachidanandam, Arlene A. Gayle, H. Ian Robins, Jill M. Kolesar

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8 Scopus citations

Abstract

The anthracycline anticancer agent doxorubicin has long been recognized to induce a dose-limiting cardiotoxicity and may be associated with genes relevant to doxorubicin disposition. Recent reports suggest a role for a number of single nucleotide polymorphisms in anthracycline cardiotoxicity in children. We describe two adult sisters with anthracycline cardiotoxicity that developed after a relatively low dose of doxorubicin. One sister carried the variant genotype for histamine N-ethyl transferase (HNMT, rs17583889) while the other was heterozygous, suggesting a similar role for these genotypes in adults with anthracycline cardiotoxicity. Although this requires further study, these genotypes may be important in the clinical dosing, or use of the liposomal formulation of doxorubicin.

Original language	English
Pages (from-to)	269-272
Number of pages	4
Journal	Journal of Oncology Pharmacy Practice
Volume	19
Issue number	3
DOIs	https://doi.org/10.1177/1078155212461022
State	Published - Sep 2013

Bibliographical note

Funding Information:
This work was supported in part by NIH/NCI P30 CA014520 to the UW Carbone Cancer Center.

Keywords

Doxorubicin
cardiotoxicity
polymorphism

ASJC Scopus subject areas

Oncology
Pharmacology (medical)

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abstract = "The anthracycline anticancer agent doxorubicin has long been recognized to induce a dose-limiting cardiotoxicity and may be associated with genes relevant to doxorubicin disposition. Recent reports suggest a role for a number of single nucleotide polymorphisms in anthracycline cardiotoxicity in children. We describe two adult sisters with anthracycline cardiotoxicity that developed after a relatively low dose of doxorubicin. One sister carried the variant genotype for histamine N-ethyl transferase (HNMT, rs17583889) while the other was heterozygous, suggesting a similar role for these genotypes in adults with anthracycline cardiotoxicity. Although this requires further study, these genotypes may be important in the clinical dosing, or use of the liposomal formulation of doxorubicin.",

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AU - Gayle, Arlene A.

AU - Robins, H. Ian

AU - Kolesar, Jill M.

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AB - The anthracycline anticancer agent doxorubicin has long been recognized to induce a dose-limiting cardiotoxicity and may be associated with genes relevant to doxorubicin disposition. Recent reports suggest a role for a number of single nucleotide polymorphisms in anthracycline cardiotoxicity in children. We describe two adult sisters with anthracycline cardiotoxicity that developed after a relatively low dose of doxorubicin. One sister carried the variant genotype for histamine N-ethyl transferase (HNMT, rs17583889) while the other was heterozygous, suggesting a similar role for these genotypes in adults with anthracycline cardiotoxicity. Although this requires further study, these genotypes may be important in the clinical dosing, or use of the liposomal formulation of doxorubicin.

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Unexpected doxorubicin-mediated cardiotoxicity in sisters: Possible role of polymorphisms in histamine n-methyl transferase

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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