Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells

Jin Ishizuka; R. Daniel Beauchamp; B. Mark Evers; Courtney M. Townsend; James C. Thompson

doi:10.1016/0006-291X(92)91663-B

Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells

Jin Ishizuka, R. Daniel Beauchamp, B. Mark Evers, Courtney M. Townsend, James C. Thompson

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial. In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic nude mice. In the present study, however, SMS 201-995 did not inhibit in vitro growth of BON cells, but rather SMS 201-995 stimulated growth in a dose-dependent fashion. The growth-stimulatory effect was likely mediated through the reduction of cyclic AMP production. Unsuccessful treatment of certain types of carcinoid tumor with SMS 201-995 may be partly due to the direct growth-stimulatory effect of SMS 201-995 on carcinoid cells.

Original language	English
Pages (from-to)	577-581
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	185
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(92)91663-B
State	Published - Jun 15 1992

Bibliographical note

Funding Information:
This work was supported by grants from the National Institutes of Health (NIH) (PO1 DK 35608, 5R37 DK15241), the American Cancer Society (PDT-220) and the John Sealy Endowment Fund. The authors would like to thank Jell Hsieh for her technical assistance and Sherry Carter for her assistance in the preparation of this manuscript.

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells",

abstract = "Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial. In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic nude mice. In the present study, however, SMS 201-995 did not inhibit in vitro growth of BON cells, but rather SMS 201-995 stimulated growth in a dose-dependent fashion. The growth-stimulatory effect was likely mediated through the reduction of cyclic AMP production. Unsuccessful treatment of certain types of carcinoid tumor with SMS 201-995 may be partly due to the direct growth-stimulatory effect of SMS 201-995 on carcinoid cells.",

author = "Jin Ishizuka and Beauchamp, {R. Daniel} and Evers, {B. Mark} and Townsend, {Courtney M.} and Thompson, {James C.}",

note = "Funding Information: This work was supported by grants from the National Institutes of Health (NIH) (PO1 DK 35608, 5R37 DK15241), the American Cancer Society (PDT-220) and the John Sealy Endowment Fund. The authors would like to thank Jell Hsieh for her technical assistance and Sherry Carter for her assistance in the preparation of this manuscript.",

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AU - Evers, B. Mark

AU - Townsend, Courtney M.

AU - Thompson, James C.

N1 - Funding Information: This work was supported by grants from the National Institutes of Health (NIH) (PO1 DK 35608, 5R37 DK15241), the American Cancer Society (PDT-220) and the John Sealy Endowment Fund. The authors would like to thank Jell Hsieh for her technical assistance and Sherry Carter for her assistance in the preparation of this manuscript.

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Y1 - 1992/6/15

N2 - Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial. In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic nude mice. In the present study, however, SMS 201-995 did not inhibit in vitro growth of BON cells, but rather SMS 201-995 stimulated growth in a dose-dependent fashion. The growth-stimulatory effect was likely mediated through the reduction of cyclic AMP production. Unsuccessful treatment of certain types of carcinoid tumor with SMS 201-995 may be partly due to the direct growth-stimulatory effect of SMS 201-995 on carcinoid cells.

AB - Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial. In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic nude mice. In the present study, however, SMS 201-995 did not inhibit in vitro growth of BON cells, but rather SMS 201-995 stimulated growth in a dose-dependent fashion. The growth-stimulatory effect was likely mediated through the reduction of cyclic AMP production. Unsuccessful treatment of certain types of carcinoid tumor with SMS 201-995 may be partly due to the direct growth-stimulatory effect of SMS 201-995 on carcinoid cells.

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Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells

Abstract

Bibliographical note

ASJC Scopus subject areas

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